HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | VPS36,IL2RG,EHD1A,CAPZB,ARFGAP3,HGS,ARR3A,GRK1A,VPS26B,CHMP5B |
| Antigen processing and presentation | KLRC3,RFXANK,PSME2,KIR3DL1,CTSL1,NFYC,HLA-DRB1,RFXAP,TAP2,HLA-G |
| Epstein-Barr virus infection | GTF2E1,MAP3K14,IRF3,PIK3CG,GSK3B,NEDD4,TRAF2,YWHAB,PLCG2,POLR3D |
| Autoi | IFNA4,IFNA13,FAS,IFNA5,HLA-DRA,PRF1,HLA-B,HLA-DPA1,HLA-DQB1,GZMB |
| HTLV-I infection | ANAPC11,HLA-B,MSX2,TERT,CD40,AKT1,PPP3R1,VCAM1,HLA-DQB1,XBP1 |
| ne thyroid disease | IFNA2,CD40LG,IFNA21,HLA-DRA,HLA-DRB5,IFNA4,HLA-DMA,HLA-DMB,HLA-DPA1,TSHB |
| Cell adhesion molecules (CAMs) | NLGN3A,NCAM1A,NEO1A,ITGB7,CD99,ALCAM,CLDNH,VTCN1,HLA-DRB1,ICAM2 |
| Viral carcinogenesis | STAT5A,ACTN1,PKM,CREB3L1,GTF2A2,RBL1,KAT2B,YWHAZ,HIST1H2BP,NRAS |
| Herpes simplex infection | UBE2R2,PPP1CC,SRSF5,OAS3,IFNAR2,HLA-DOB,IFNA1,HLA-DQA2,CLOCKB,RELA |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide antigen binding | H2-Q10,H2-AA,MHC1UJA,MHC1UEA,MHC1ZFA,HLA-DPB1,MHC1UDA,HLA-DRA,HLA-E,BF2 |
| TAP1 binding | TAPBP,TAP2,TAP1 |
| receptor binding | TNFSF13B,GSTM7,MTSS1,RASA1,FGF18A,CD200,BMP2,FRK,WNT2BB,AMN |
| TAP2 binding | TAPBP,TAP1 |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
