HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | Casp3,IL15,HLA-DRB4,FADD,EIF2S1B,ARNTL,MHC2DCB,C5,IL12BA,TBPL2 |
| Type I diabetes mellitus | HLA-A,FAS,FASLG,PTPRN2,IL1A,IL1B,H2-AA,Fasl,HLA-B,HSPD1 |
| ne thyroid disease | CD86,H2-AA,IFNA5,CD28,HLA-DRB4,CD40,HLA-DQA2,Fasl,IFNA16,HLA-DRB5 |
| HTLV-I infection | FZD2,WNT2B,NFATC4,ELK4,DLG1,TSPO,HLA-DQB1,PRKACG,WNT6,SFPI1 |
| Viral carcinogenesis | HIST2H2BE,KAT2B,ATF4,HDAC2,HIST1H4J,HIST1H2BM,RBL2,STAT3,PKM2,PIK3R5 |
| Autoi | IFNA7,IFNA4,CD40LG,HLA-DMB,HLA-E,CD28,HLA-DRB4,IFNA8,HLA-DOB,HLA-A |
| Allograft rejection | H2-AB1,PRF1,GZMB,HLA-DPB1,IL12B,Fasl,IL5,TNF,CD86,MICA |
| Endocytosis | CYTH4B,STAM,PRKCZ,SPG20A,IGF1R,SNF8,MVB12BB,AGAP2,EHD3,CAPZA3 |
| Phagosome | C1R,HLA-G,C3A.3,MHC1UXA2,ATP6V1C2,TLR2,CTSSA,CTSL1B,CLEC4M,ITGA5 |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | HRG,APLN,GNPAT,DAO,SLC9A3R1,GFRA1,ADIPOQ,FGF1B,RSPO1,PVRL2L |
| peptide antigen binding | MHC1UBA,HLA-DQB1,MHC1UFA,H2-Q10,MHC1ZKA,MHC1UJA,BF2,DHCR24,HLA-B,MHC1ZDA |
| TAP1 binding | TAP2,TAPBP,TAP1 |
| TAP2 binding | TAP1,TAPBP |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
