HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | APC2,TNFRSF1A,CREM,PTTG1,PPP3R1,DVL3,NFKB1,CD3D,HLA-DRB5,NFKBIA |
| Autoi | HLA-DQA1,Fasl,IFNA16,HLA-DOA,IFNA8,H2-AB1,HLA-E,HLA-C,H2-AA,CD40 |
| Graft-versus-host disease | HLA-E,HLA-DMA,PRF1,IL6,HLA-C,Fasl,H2-AB1,CD86,HLA-B,H2-Q10 |
| Cell adhesion molecules (CAMs) | NEO1,CTLA4,HLA-DQA2,CLDN14,ICAM2,PVRL3,ICAM3,CLDN7A,HLA-DQB1,ITGA6B |
| Type I diabetes mellitus | GZMB,HLA-DRA,GAD1,HLA-DQA1,CD86,INS1,Fasl,IL12B,H2-Q10,HLA-G |
| Allograft rejection | H2-AA,HLA-DMA,IL12B,MICA,GZMB,CD40LG,HLA-DRB5,HLA-DQB1,HLA-DRA,IL12A |
| Viral carcinogenesis | GTF2A1L,POLB,RAC1,HDAC3,HDAC4,TRADD,KAT2A,PIK3R2,GTF2H2C_2,CCNA2 |
| Phagosome | RAB5C,FCGR2A,NOX3,HLA-DQA2,DYNC1I2A,HLA-C,MHC2DAB,NOX1,MBL1,CALRL2 |
| Viral myocarditis | HLA-DPA1,HLA-DRB5,HLA-DRB4,PRF1,CASP8,ITGB2L,Casp3,HLA-C,ACTB,HLA-E |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP1 binding | TAP1,TAPBP,TAP2 |
| TAP2 binding | TAPBP,TAP1 |
| receptor binding | WNT4B,RARRES2,TNFSF9,CD2,CD58,LGI1,UFD1L,LAMA4,KCNA5,PPP2R4 |
| peptide antigen binding | HLA-DRB1,MHC1ZFA,BF2,MAML1,MHC1UXA2,CD209,MHC1UFA,HLA-DRA,HLA-G,MHC1UKA |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
