HIST1H4E
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Official Full Name
HIST1H4E histone cluster 1, H4e [ Homo sapiens ] -
Overview
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. -
Synonyms
histone cluster 1, H4e;4790;Ensembl:ENSG00000198518;histone H4;histone 1, H4e;H4 histone family, member J;H4/j;H4FJ
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HIST1H4E-13798H | Recombinant Human HIST1H4E, GST-tagged | E.coli | Human | GST | 1-103a.a. | |
| HIST1H4E-5525HCL | Recombinant Human HIST1H4E 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
HIST1H4E involved in several pathways and played different roles in them. We selected most pathways HIST1H4E participated on our site, such as Alcoholism,Viral carcinogenesis,Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIST1H4E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Systemic lupus erythematosus | ELANE,SNRPB,HIST1H2BE,H2AFJ,HLA-DQA2,C1S,H2BFWT,HIST1H3F,HIST1H2AH,HIST2H4A |
| Alcoholism | CREB3L2,H3F3A,HDAC4,GNGT2,SHC4,HIST1H2BA,HDAC7A,NTRK2,CAMKK2,GNAI1 |
| Viral carcinogenesis | PIK3R1,HIST1H4D,MAD1L1,HIST1H2BC,EGR3,HIST1H2BQ,HIST1H4N,HIST1H2BE,ATF4,HIST1H4H |
Protein Function
HIST1H4E has several biochemical functions, for example, DNA binding,histone binding,histone demethylase activity (H4-K20 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by HIST1H4E itself. We selected most functions HIST1H4E had, and list some proteins which have the same functions with HIST1H4E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone demethylase activity (H4-K20 specific) | PHF8,JHDM1D,HIST1H4B,HIST2H4A,HIST1H4K,HIST1H4I,HIST1H4A,HIST1H4F,HIST1H4H,HIST1H4J |
| protein binding | NUP85,FKBP5,PSMC4,TNK2,ZBTB43,AIRE,TJP2,MICALL1,AGO2,EIF3A |
| poly(A) RNA binding | NSA2,FARSA,RPL15,HNRNPM,MTAP4,RRP8,SRP72,ALDOA,HIST1H1D,HHATL |
| protein domain specific binding | HSPA5,STMN3,PRKAR2B,SCAF1,FOXA2,TRIM11,YWHAE,CEP68,TRP63,YWHAG |
| DNA binding | ZBTB8B,HOXA13B,HIST2H2BE,Trl,SP6,THOC1,ZFPM2,HIST1H47,HOXB4A,PCBP2 |
| histone binding | CTSL2,HIST1H4A,H3F3B,HIST1H4C,PRKCBB,BAZ2A,SMARCA4A,TONSL,RBBP4,SART3 |
| protein heterodimerization activity | UGT1A7,HMG20A,H2AFJ,NKX2,NEFL,TFDP3,HIST1H4L,CA,MCL1A,ATF3 |
Interacting Protein
HIST1H4E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIST1H4E here. Most of them are supplied by our site. Hope this information will be useful for your research of HIST1H4E.
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