HIF3A
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Official Full Name
hypoxia inducible factor 3, alpha subunit -
Overview
The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011] -
Synonyms
HIF3A;hypoxia inducible factor 3, alpha subunit;IPAS;MOP7;PASD7;HIF-3A;bHLHe17;hypoxia-inducible factor 3-alpha;HIF3-alpha-1;member of PAS protein 7;inhibitory PAS domain protein;PAS domain-containing protein 7;basic-helix-loop-helix-PAS protein MOP7;class E basic helix-loop-helix protein 17
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HIF3A-2842R | Recombinant Rat HIF3A Protein | Mammalian Cell | Rat | His |
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| HIF3A-4749H | Recombinant Human HIF3A Protein, GST-tagged | Wheat Germ | Human | GST |
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| HIF3A-5563HCL | Recombinant Human HIF3A 293 Cell Lysate | HEK293 | Human | Non |
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| HIF3A-2497R | Recombinant Rat HIF3A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| HIF3A-2497R-B | Recombinant Rat HIF3A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| HIF3A-3468HF | Recombinant Full Length Human HIF3A Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 363 amino acids |
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Involved Pathway
HIF3A involved in several pathways and played different roles in them. We selected most pathways HIF3A participated on our site, such as Cellular response to hypoxia,Cellular responses to stress,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIF3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Hypoxia-inducible Factor (HIF) by oxygen | HIF1AN,EGLN1B,EGLN3,HIF1AL,EPAS1B,EGLN2 |
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | NAA10,GNB2L1,HIF1AN,COPS5 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | EGLN1B,EGLN2,HIF1AL,EGLN3,EPAS1B |
| Cellular response to hypoxia | EPAS1B,HIF1AL,EGLN1B,HIF1AN,EGLN2,EGLN3 |
| Regulation of gene expression by Hypoxia-inducible Factor | EPAS1B,HIF1AL |
| Transcriptional regulation of pluripotent stem cells | PRDM14,LIN28A,SALL4,POU5F3,TDGF1,FOXD3,NR5A1,NR6A1 |
| Cellular responses to stress | EPAS1B,HSBP1,HIST3H2BB,CHMP4B,GABARAPL2,TINF2,MAP1LC3B,KIAA1967,HSPA14,RB1CC1 |
| Developmental Biology | KALRNB,CAP1,SEMA3AA,AP2M1,CDK5R1B,PTPRA,SREBF2,TCF3A,RHOB,KLB |
Protein Function
HIF3A has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HIF3A itself. We selected most functions HIF3A had, and list some proteins which have the same functions with HIF3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | RYBP,YAP1,KLF12,RCOR2,TBL1Y,TLE2,CCAR1,CRYM,SETD8,YWHAB |
| DNA binding | ZNF69,ERCC2,ZNF238,FOXD5,ATF4B1,HIST1H2BK,SIM2,TOP1,ZNF559,ANKRD1 |
| protein dimerization activity | SREBF2,OLIG3,PDCD6,HES7,ARNTL1B,NCF4,HES6,DNM1,POLR1D,ID4 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | SPI1A,TRP53,ZNF576,JUNBB,FOXA3,ATF4B1,MEF2A,ZSCAN5A,OVOL3,FOXO3A |
| transcription coactivator activity | SMARCB1,FUS,BRCA1,MED7,HINFP,TAF7,ECD,WWC1,ATXN7L3,NFKB2 |
Interacting Protein
HIF3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIF3A here. Most of them are supplied by our site. Hope this information will be useful for your research of HIF3A.
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References
- Shida, T; Nozawa, T; et al. Fluvastatin-induced reduction of oxidative stress ameliorates diabetic cardiomyopathy in association with improving coronary microvasculature. HEART AND VESSELS 29:532-541(2014).
- Li, JP; Li, FYL; et al. Lipopolysaccharide and Hypoxia-Induced HIF-1 Activation in Human Gingival Fibroblasts. JOURNAL OF PERIODONTOLOGY 83:816-824(2012).
