HHAT

  • Official Full Name

    hedgehog acyltransferase

  • Overview

    Skinny hedgehog (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of hedgehog (see MIM 600725).

  • Synonyms

    HHAT;hedgehog acyltransferase;protein-cysteine N-palmitoyltransferase HHAT;FLJ10724;GUP2;MART 2;MART2;rasp;sit;ski;Skn;2810432O22Rik;AI462858;FLJ34867;AC115917.1;HHAT_HUMAN;MART-2;Melanoma antigen recognized by T cells 2;Melanoma antigen recognized by T-cells 2;MGC11697;OTTMUSP00000033669;Protein cysteine N palmitoyltransferase HHAT;RGD1311746;SKI1;Skinny hedgehog protein 1;Skinny hedgehog protein;OTTHUMP00000034608;OTTHUMP00000034611
Cat.# Product name Source (Host) Species Tag Protein Length Price
HHAT-255H Recombinant Human HHAT Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
HHAT-6488Z Recombinant Zebrafish HHAT Mammalian Cells Zebrafish His
HHAT-7609M Recombinant Mouse HHAT Protein Mammalian Cells Mouse His
Hhat-3389M Recombinant Mouse Hhat Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
HHAT-4149M Recombinant Mouse HHAT Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
HHAT-4149M-B Recombinant Mouse HHAT Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    HHAT involved in several pathways and played different roles in them. We selected most pathways HHAT participated on our site, such as Hedgehog ligand biogenesis,Signal Transduction,Signaling by Hedgehog, which may be useful for your reference. Also, other proteins which involved in the same pathway with HHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hedgehog ligand biogenesis DISP2,NOTUM,SCUBE2,GPC5A,DERL2,OS9,NOTUM1A
    Signal Transduction METAP2,ARHGAP32,IGF2BP1,IFT122,ARHGAP24,ROR2,CCNT2A,GPR18,CRABP1B,CCL35.1
    Signaling by Hedgehog IFT52,KIF7,WDR35,IFT88,BOC,EVC,EFCAB7,NOTUM,BBS13,GPR161

    Protein Function

    HHAT has several biochemical functions, for example, 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity,2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity,2-methylhexanoyl-CoA C-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HHAT itself. We selected most functions HHAT had, and list some proteins which have the same functions with HHAT. You can find most of the proteins on our site.

    Function Related Protein
    keto acid formate lyase activity CML5,MBOAT7,MBOAT4,MBOAT1,LPCAT3,NAT14,DGAT2L6,CML2,ACNAT2,Acnat1
    C-acyltransferase activity DGAT2L6,MBOAT1,LPCAT3,CML5,CML2,MBOAT7,ACNAT2,Acnat1,NAT14,MBOAT4
    peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor MBOAT1,LPCAT3,MBOAT7,NAA50,MBOAT4,ACNAT2,CML5,DGAT2L6,NAT14,Acnat1
    naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity MBOAT1,MBOAT7,MBOAT4,DGAT2L6,ACNAT2,CML2,NAT14,CML5,Acnat1,LPCAT3
    glucosaminyl-phosphotidylinositol O-acyltransferase activity NAT14,ACNAT2,MBOAT1,Acnat1,CML5,LPCAT3,MBOAT7,MBOAT4,CML2,DGAT2L6
    Ras palmitoyltransferase activity CML2,ACNAT2,CML5,LPCAT3,Acnat1,ZDHHC9,MBOAT4,MBOAT1,MBOAT7,DGAT2L6
    O-acyltransferase activity NAT14,PLA2G15,CML5,MBOAT4,LPCAT3,DGAT1B,DGAT2L6,DGAT1A,MBOAT1,ACNAT2
    palmitoyltransferase activity CML2,ZDHHC7,DGAT2L6,ZDHHC16,ZDHHC1,ZDHHC5,MBOAT1,MBOAT7,ZDHHC20,ZDHHC3
    acyl-CoA N-acyltransferase activity ACNAT2,MBOAT1,NAT14,CML2,LPCAT3,DGAT2L6,Acnat1,MBOAT7,CML5,MBOAT4

    Interacting Protein

    HHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of HHAT.

    Resources

    Research Area

    Tumor Antigens

    References

    • Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All HHAT Products

    Required fields are marked with *

    My Review for All HHAT Products

    Required fields are marked with *