HHAT

  • Official Full Name

    hedgehog acyltransferase
  • Overview

    Skinny hedgehog (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of hedgehog (see MIM 600725).
  • Synonyms

    HHAT;hedgehog acyltransferase;protein-cysteine N-palmitoyltransferase HHAT;FLJ10724;GUP2;MART 2;MART2;rasp;sit;ski;Skn;2810432O22Rik;AI462858;FLJ34867;AC115917.1;HHAT_HUMAN;MART-2;Melanoma antigen recognized by T cells 2;Melanoma antigen recognized by T-cells 2;MGC11697;OTTMUSP00000033669;Protein cysteine N palmitoyltransferase HHAT;RGD1311746;SKI1;Skinny hedgehog protein 1;Skinny hedgehog protein;OTTHUMP00000034608;OTTHUMP00000034611
Cat.# Product name Source (Host) Species Tag Protein Length Price
HHAT-255H Recombinant Human HHAT Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
HHAT-6488Z Recombinant Zebrafish HHAT Mammalian Cells Zebrafish His
HHAT-7609M Recombinant Mouse HHAT Protein Mammalian Cells Mouse His
Hhat-3389M Recombinant Mouse Hhat Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
HHAT-4149M Recombinant Mouse HHAT Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
HHAT-4149M-B Recombinant Mouse HHAT Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    HHAT involved in several pathways and played different roles in them. We selected most pathways HHAT participated on our site, such as Hedgehog ligand biogenesis,Signal Transduction,Signaling by Hedgehog, which may be useful for your reference. Also, other proteins which involved in the same pathway with HHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling by Hedgehog GPR161,WDR19,TULP3,GAS8,CDON,IFT172,SPOPL,SPOP,IFT52,BBS13
    Hedgehog ligand biogenesis GPC5A,DISP2,DERL2,NOTUM,OS9,NOTUM1A,SCUBE2
    Signal Transduction C,NRP2A,PROKR1,SH2B3,HEBP1,SCUBE2,OPN1LW1,KIF7,OR10A5,ARHGAP4

    Protein Function

    HHAT has several biochemical functions, for example, 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity,2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity,2-methylhexanoyl-CoA C-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HHAT itself. We selected most functions HHAT had, and list some proteins which have the same functions with HHAT. You can find most of the proteins on our site.

    Function Related Protein
    N-succinyltransferase activity MBOAT7,LPCAT3,DGAT2L6,Acnat1,ACNAT2,MBOAT4,NAT14,MBOAT1,CML5,CML2
    serine O-acyltransferase activity MBOAT7,Acnat1,MBOAT1,CML5,ACNAT2,MBOAT4,LPCAT3,DGAT2L6,NAT14,CML2
    acylglycerol O-acyltransferase activity CML2,MBOAT7,LPCAT3,MBOAT1,MBOAT4,CML5,NAT14,DGAT2L6,ACNAT2,Acnat1
    benzoyl acetate-CoA thiolase activity Acnat1,MBOAT1,DGAT2L6,MBOAT4,NAT14,LPCAT3,ACNAT2,MBOAT7,CML5,CML2
    O-acetyltransferase activity NAT14,CML5,DGAT2L6,MBOAT4,MBOAT7,LPCAT3,MBOAT1,CML2,Acnat1,ACNAT2
    S-malonyltransferase activity LPCAT3,Acnat1,MBOAT1,CML2,ACNAT2,NAT14,MBOAT4,DGAT2L6,MBOAT7,CML5
    keto acid formate lyase activity LPCAT3,CML5,ACNAT2,Acnat1,MBOAT1,MBOAT7,MBOAT4,DGAT2L6,NAT14,CML2
    naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity CML5,MBOAT1,NAT14,Acnat1,CML2,ACNAT2,DGAT2L6,MBOAT4,LPCAT3,MBOAT7
    peptidyl-lysine N6-palmitoyltransferase activity ACNAT2,CML5,LPCAT3,MBOAT1,DGAT2L6,Acnat1,NAT14,MBOAT7,MBOAT4,CML2

    Interacting Protein

    HHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of HHAT.

    Resources

    Research Area

    Tumor Antigens

    References

    • Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).

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