HHAT

  • Official Full Name

    hedgehog acyltransferase

  • Overview

    Skinny hedgehog (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of hedgehog (see MIM 600725).

  • Synonyms

    HHAT;hedgehog acyltransferase;protein-cysteine N-palmitoyltransferase HHAT;FLJ10724;GUP2;MART 2;MART2;rasp;sit;ski;Skn;2810432O22Rik;AI462858;FLJ34867;AC115917.1;HHAT_HUMAN;MART-2;Melanoma antigen recognized by T cells 2;Melanoma antigen recognized by T-cells 2;MGC11697;OTTMUSP00000033669;Protein cysteine N palmitoyltransferase HHAT;RGD1311746;SKI1;Skinny hedgehog protein 1;Skinny hedgehog protein;OTTHUMP00000034608;OTTHUMP00000034611
Cat.# Product name Source (Host) Species Tag Protein Length Price
HHAT-255H Recombinant Human HHAT Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
HHAT-6488Z Recombinant Zebrafish HHAT Mammalian Cells Zebrafish His
HHAT-7609M Recombinant Mouse HHAT Protein Mammalian Cells Mouse His
Hhat-3389M Recombinant Mouse Hhat Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
HHAT-4149M Recombinant Mouse HHAT Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
HHAT-4149M-B Recombinant Mouse HHAT Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    HHAT involved in several pathways and played different roles in them. We selected most pathways HHAT participated on our site, such as Hedgehog ligand biogenesis,Signal Transduction,Signaling by Hedgehog, which may be useful for your reference. Also, other proteins which involved in the same pathway with HHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signal Transduction SST,GHRB,INSL3,ARHGAP29,FSTL1B,DRAP1,GPBAR1,ARHGAP33,OR10A5,ARHGAP17A
    Hedgehog ligand biogenesis NOTUM1A,DERL2,GPC5A,OS9,DISP2,NOTUM,SCUBE2
    Signaling by Hedgehog IFT172,MKS1,CDON,TULP3,SCUBE2,EFCAB7,DISP2,INTU,EVC2,IFT88

    Protein Function

    HHAT has several biochemical functions, for example, 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity,2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity,2-methylhexanoyl-CoA C-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HHAT itself. We selected most functions HHAT had, and list some proteins which have the same functions with HHAT. You can find most of the proteins on our site.

    Function Related Protein
    O-octanoyltransferase activity MBOAT1,MBOAT4,DGAT2L6,Acnat1,CML2,MBOAT7,NAT14,ACNAT2,LPCAT3,CML5
    Ras palmitoyltransferase activity CML5,LPCAT3,MBOAT7,NAT14,ZDHHC9,Acnat1,CML2,ACNAT2,MBOAT4,DGAT2L6
    palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity Acnat1,CML2,MBOAT1,NAT14,MBOAT4,DGAT2L6,CML5,LPCAT3,ACNAT2,MBOAT7
    2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity CML5,NAT14,MBOAT1,LPCAT3,MBOAT7,CML2,DGAT2L6,Acnat1,ACNAT2,MBOAT4
    butyryl-CoA 2-C-propionyltransferase activity MBOAT7,MBOAT1,ACNAT2,CML5,MBOAT4,DGAT2L6,NAT14,CML2,Acnat1,LPCAT3
    transferase activity, transferring acyl groups DGAT2L6,ZDHHC6,CML2,ZDHHC14,AANAT,CHATA,ZDHHC18A,ZDHHC3A,TGM3,ZDHHC8B
    L-2-aminoadipate N-acetyltransferase activity CML2,MBOAT1,ACNAT2,Acnat1,LPCAT3,CML5,DGAT2L6,NAT14,MBOAT4,MBOAT7
    sinapoyltransferase activity Acnat1,ACNAT2,DGAT2L6,MBOAT4,CML5,NAT14,MBOAT1,MBOAT7,LPCAT3,CML2
    O-succinyltransferase activity Acnat1,LPCAT3,MBOAT1,CML2,CML5,ACNAT2,MBOAT4,NAT14,DGAT2L6,MBOAT7

    Interacting Protein

    HHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of HHAT.

    Resources

    Research Area

    Tumor Antigens

    References

    • Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).

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