HERC3
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Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 3 -
Overview
HERC3 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM;179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with;ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange;factor for small G proteins (Hochrainer et al., 2005 (PubMed 15676274)). -
Synonyms
HERC3;HECT and RLD domain containing E3 ubiquitin protein ligase 3;hect domain and RLD 3;probable E3 ubiquitin-protein ligase HERC3;KIAA0032;HECT domain and RCC1-like domain-containing protein 3
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HERC3-13738H | Recombinant Human HERC3, GST-tagged | E.coli | Human | GST | 1-368a.a. | |
| HERC3-2067R | Recombinant Rhesus monkey HERC3 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| HERC3-3358C | Recombinant Chicken HERC3 | Mammalian Cells | Chicken | His |
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| HERC3-4691H | Recombinant Human HERC3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HERC3-7363Z | Recombinant Zebrafish HERC3 | Mammalian Cells | Zebrafish | His |
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| HERC3-780HCL | Recombinant Human HERC3 cell lysate | Human | Non |
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| HERC3-1888R | Recombinant Rhesus Macaque HERC3 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| HERC3-1888R-B | Recombinant Rhesus Macaque HERC3 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
HERC3 involved in several pathways and played different roles in them. We selected most pathways HERC3 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HERC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | RHOBTB1,UBE2D1B,UBE2G1,ANAPC2,BIRC2,CBL,UBE2D2A,PML,CUL4B,FZR1A |
Protein Function
HERC3 has several biochemical functions, for example, ligase activity,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC3 itself. We selected most functions HERC3 had, and list some proteins which have the same functions with HERC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | RNF19B,UBE2T,RNF152,RNF181,RNF126,TRIM63,RNF34,TRAF6,HECW1,BRAP |
| ligase activity | MARCH10,WWP1,ATG10,BRCA1,RFWD2,PRP19,TRIM5,RNF220,RNF139,CNOT4 |
Interacting Protein
HERC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC3.
UBC;CCL22;TK1;CD33
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