HERC2
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Official Full Name
hect domain and RLD 2 -
Overview
This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. -
Synonyms
HERC2;hect domain and RLD 2;E3 ubiquitin-protein ligase HERC2;D15F37S1;jdf2;p528;HECT domain and RCC1 like domain containing protein 2;SHEP1;probable E3 ubiquitin-protein ligase HERC2;hect domain and RCC1-like domain-containing protein 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HERC2-4573C | Recombinant Chicken HERC2 | Mammalian Cell | Chicken | His |
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| HERC2-7580M | Recombinant Mouse HERC2 Protein | Mammalian Cell | Mouse | His |
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| HERC2-0432H | Recombinant Human HERC2 Protein (S3951-P4321), Tag Free | E.coli | Human | Non | S3951-P4321 |
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| HERC2-0433H | Recombinant Human HERC2 Protein (S3951-P4321), His tagged | E.coli | Human | His | S3951-P4321 |
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| HERC2-4127M | Recombinant Mouse HERC2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HERC2-4127M-B | Recombinant Mouse HERC2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HERC2 involved in several pathways and played different roles in them. We selected most pathways HERC2 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HERC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | XIAP,SMURF2,BIRC8,UBE2D2,CUL1,CUL5,CUL3,HERC3,UBE2D2A,TRAF6 |
Protein Function
HERC2 has several biochemical functions, for example, SUMO binding,UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC2 itself. We selected most functions HERC2 had, and list some proteins which have the same functions with HERC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein-glutamic acid ligase activity | TRIM41,RNF144AB,RNF180,MUL1A,UBE2IB,ZNRF2B,MGRN1A,SHRPRBCK1R,SIAH2L,TRIM50 |
| protein-glycine ligase activity, initiating | MARCH9,TMEM129,UBE2IA,MGRN1A,ITCHA,SIAH2L,ZNRF2B,LTN1,MYLIPB,RNF180 |
| SUMO binding | USP25,USPL1,TDG,CBX4,RPS3,TOLLIP,PML |
| protein-glycine ligase activity | ITCHA,RFWD2,TMEM129,MGRN1A,TRIM41,SHRPRBCK1R,HECW2,UBE2IB,MYLIPB,RC3H2 |
| tubulin-glycine ligase activity | RNF149,MUL1A,SHRPRBCK1R,FLR,NEURL3,MYLIPA,TMEM129,LTN1,TRIM71,UBR1 |
| ribosomal S6-glutamic acid ligase activity | TMEM129,RNF144AB,MARCH6,MGRN1A,MARCH11,RC3H2,HECW2,RNF144AA,MYLIPA,NEURL1B |
| ubiquitin protein ligase binding | USP13,AURKA,RNF40,CDC34A,TOLLIP,BCL2,PRKACB,USP25,FAF2,USP2 |
| ubiquitin-protein transferase activity | FBXW11,SMURF1,CBL,RNF4,UBA7,FBXL14A,ZNF738,CBLB,AMFR,TRIM37 |
| protein-glycine ligase activity, elongating | SIAH2L,MARCH11,MARCH9,G2E3,RAG1,SHRPRBCK1R,RNF187,TMEM129,SIAH1A,RNF144AA |
Interacting Protein
HERC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC2.
NEURL4;ZBTB5;SSSCA1;SFN;ESCO1
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References
- Moroishi, T; Yamauchi, T; et al. HERC2 Targets the Iron Regulator FBXL5 for Degradation and Modulates Iron Metabolism. JOURNAL OF BIOLOGICAL CHEMISTRY 289:16430-16441(2014).
- Long, Y; Wang, YB; et al. Neurotoxicity of Perfluorooctane Sulfonate to Hippocampal Cells in Adult Mice. PLOS ONE 8:-(2013).
