HERC2

  • Official Full Name

    hect domain and RLD 2

  • Overview

    This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability.

  • Synonyms

    HERC2;hect domain and RLD 2;E3 ubiquitin-protein ligase HERC2;D15F37S1;jdf2;p528;HECT domain and RCC1 like domain containing protein 2;SHEP1;probable E3 ubiquitin-protein ligase HERC2;hect domain and RCC1-like domain-containing protein 2
Cat.# Product name Source (Host) Species Tag Protein Length Price
HERC2-4573C Recombinant Chicken HERC2 Mammalian Cells Chicken His
HERC2-7580M Recombinant Mouse HERC2 Protein Mammalian Cells Mouse His
HERC2-0432H Recombinant Human HERC2 Protein (S3951-P4321), Tag Free E.coli Human Non S3951-P4321
HERC2-0433H Recombinant Human HERC2 Protein (S3951-P4321), His tagged E.coli Human His S3951-P4321
HERC2-4127M Recombinant Mouse HERC2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
HERC2-4127M-B Recombinant Mouse HERC2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    HERC2 involved in several pathways and played different roles in them. We selected most pathways HERC2 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HERC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis CDC20,UBE4B,HERC3,FBXW7,UBE2O,FBXW11A,UBE2D2A,UBE2IB,CUL4A,UBE2L3A

    Protein Function

    HERC2 has several biochemical functions, for example, SUMO binding,UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC2 itself. We selected most functions HERC2 had, and list some proteins which have the same functions with HERC2. You can find most of the proteins on our site.

    Function Related Protein
    protein-glycine ligase activity, elongating RFWD2,RNF169,DTX1,NEURL3,MGRN1A,RNF144AA,MARCH4,NEURL1B,SIAH1A,RC3H2
    ubiquitin protein ligase activity UBE3B,RNF13,WWP2,MED21,RNF175,MSL2A,PDZD4,RFWD2,HACE1,RNF34
    tubulin-glutamic acid ligase activity RNF180,UBR1,TRIM50,NEURL1B,TMEM129,RAG1,SHRPRBCK1R,G2E3,RNF169,NEURL3
    ligase activity NEURL3,TRAIP,ZNRF3,RNF213,MID2,XIAP,HECW1B,PPIL2,MKRN3,FPGS
    tubulin-glycine ligase activity SIAH2L,RNF169,ITCHA,RC3H2,RAG1,MARCH4,MARCH11,MYLIPA,MARCH5L,MUL1A
    protein-glutamic acid ligase activity ARIH1L,TRIM41,MUL1A,RNF144AB,SIAH2L,MARCH5L,RNF144AA,UBE2IB,MYLIPA,RNF149
    ubiquitin protein ligase binding SQSTM1,SCAMP3,PARK2,GRIK2,MID1,RRAGA,TRAF5,CXCR4,MDM2,CASC3
    ribosomal S6-glutamic acid ligase activity MGRN1A,NEURL3,SIAH2L,MARCH6,LTN1,DTX1,RFWD2,TRIM71,MARCH9,ARIH1L
    coenzyme F420-2 alpha-glutamyl ligase activity MYLIPA,MARCH5L,SIAH1A,RNF187,HECW2,UBE2IA,UBR1,RFWD2,NEURL1B,RNF180

    Interacting Protein

    HERC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC2.

    NEURL4;ZBTB5;SSSCA1;SFN;ESCO1

    Resources

    References

    • Moroishi, T; Yamauchi, T; et al. HERC2 Targets the Iron Regulator FBXL5 for Degradation and Modulates Iron Metabolism. JOURNAL OF BIOLOGICAL CHEMISTRY 289:16430-16441(2014).
    • Long, Y; Wang, YB; et al. Neurotoxicity of Perfluorooctane Sulfonate to Hippocampal Cells in Adult Mice. PLOS ONE 8:-(2013).

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