HCST
-
Official Full Name
hematopoietic cell signal transducer -
Overview
This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. -
Synonyms
HCST;hematopoietic cell signal transducer;phosphoinositide 3 kinase adaptor protein , PIK3AP;DAP10;DKFZP586C1522;DNAX activation protein 10;KAP10;kinase assoc pro of ~10kDa;Membrane protein DAP10;phosphoinositide 3 kinase adaptor protein;PIK3AP;Transmembrane adapter protein KAP10;kinase assoc protein;DNAX-activation protein 10;phosphoinositide-3-kinase adaptor protein
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- Human Cells
- Mammalian Cells
- HEK293
- His
- Non
- DDK
- Myc
- mFc
- Avi
- Fc
Involved Pathway
HCST involved in several pathways and played different roles in them. We selected most pathways HCST participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | ABI1B,KIR2DS2,GBP5,RNF216,CR1,KIF3B,TNIP2,MKRN1,CLEC4A,PRLRB |
| Natural killer cell mediated cytotoxicity | HLA-A,KIR3DL2,KIR3DL1,KLRD1,LCP2,FCER1G,IFNA1,Fasl,KLRC4-KLRK1,SH2D1A |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | LILRB2,CXADR,LILRB1,CRTAM,SIGLEC11,SIGLEC10,CD96,TREML2,RAET1E,KLRB1B |
| Adaptive Immune System | ERAP2,TPP2,MGC174857,FGF10B,UBE2U,RAP1GAP2B,RNF6,RNF111,AP2A2,AP2S1 |
Protein Function
HCST has several biochemical functions, for example, phosphatidylinositol 3-kinase binding,protein binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HCST itself. We selected most functions HCST had, and list some proteins which have the same functions with HCST. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FOXC2,LCE3E,MAGI2,PDLIM3,ERBB3,DNAJC27,BUB3,XPO6,TNPO1,UTP3 |
| receptor binding | DAO1,LAMA2,ICOSLG,PEX14,IAPP,FGF11A,CD58,TIGIT,WNT4A,TYROBP |
| phosphatidylinositol 3-kinase binding | CALM3,TYRO3,IGF1RA,PIK3R1,IGF1R,BECN1,INSRA,JAK2,ATP1A1,IRS4 |
Interacting Protein
HCST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCST here. Most of them are supplied by our site. Hope this information will be useful for your research of HCST.
KLRK1;katG
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References
- Penack, O; Fischer, L; et al. Serotherapy with thymoglobulin and alemtuzumab differentially influences frequency and function of natural killer cells after allogeneic stem cell transplantation. BONE MARROW TRANSPLANTATION 41:377-383(2008).
- Wiendl, H; Lehmann, HC; et al. Multiple sclerosis: potential therapeutic options and update of ongoing clinical trials. NERVENARZT 75:536-+(2004).
- Ishida, N; Ito, M; et al. Functional expression of human Golgi CMP sialic acid transporter in the Golgi complex of a transporter-deficient Chinese hamster ovary cell mutant. JOURNAL OF BIOCHEMISTRY 124:171-178(1998).
