HCN2
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Official Full Name
hyperpolarization activated cyclic nucleotide-gated potassium channel 2 -
Overview
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 is a protein that in humans is encoded by the HCN2 gene. -
Synonyms
HCN2;hyperpolarization activated cyclic nucleotide-gated potassium channel 2;potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Recombinant Proteins
- Rat
- Mouse
- Human
- Mammalian Cells
- HEK293
- His
- Flag
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HCN2-2807R | Recombinant Rat HCN2 Protein | Mammalian Cells | Rat | His |
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| HCN2-7520M | Recombinant Mouse HCN2 Protein | Mammalian Cells | Mouse | His |
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| HCN2-1181HFL | Recombinant Human HCN2 protein, His&Flag-tagged | HEK293 | Human | Flag&His | 1-889 aa |
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| HCN2-2462R | Recombinant Rat HCN2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| HCN2-2462R-B | Recombinant Rat HCN2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| HCN2-4083M | Recombinant Mouse HCN2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| HCN2-4083M-B | Recombinant Mouse HCN2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HCN2 involved in several pathways and played different roles in them. We selected most pathways HCN2 participated on our site, such as cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | NFKB1,GRIN2B,TSHR,ROCK1,FSHB,PIK3R2,RRAS2,GRIA2,GIPR,NPY1R |
Protein Function
HCN2 has several biochemical functions, for example, cAMP binding,identical protein binding,intracellular cAMP activated cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HCN2 itself. We selected most functions HCN2 had, and list some proteins which have the same functions with HCN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cAMP binding | CNMPD1,PDE3A,PDE4A,POPDC2,PRKAR2B,PRKAR1A,BVES,PDE4D,PDE4B,RAPGEF3 |
| voltage-gated potassium channel activity | KCNT1,KCNC1,KCNAB2B,KCNH8,KCNK9,CNGA3,KCNAB1,KCNH1B,KCNE4,KCNC1B |
| voltage-gated sodium channel activity | SCN3A,SCN11A,SCN1B,SCN1BB,SCN5A,SCN12AA,SCN2A,SCN12AB,PKD2,SCN3B |
| intracellular cAMP activated cation channel activity | HCN4,CNGA4,CNGA5,CNGA3,CNGA1 |
| identical protein binding | AHCY,WAS,CALCA,CCDC91,CLDN2,RAF1,PRPS2,JMJD6,CLDN20,ADORA2A |
Interacting Protein
HCN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HCN2.
Resources
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References
- Riesen, SC; Schober, KE; et al. Myocardial expression of hyperpolarization-activated, cyclic nucleotide-gated proteins in healthy cats and cats with hypertrophic cardiomyopathy. SCHWEIZER ARCHIV FUR TIERHEILKUNDE 155:143-147(2013).
- Yang, S; Xiong, CJ; et al. The distribution of HCN2-positive cells in the gastrointestinal tract of mice. JOURNAL OF ANATOMY 221:303-310(2012).
