HCFC2
-
Official Full Name
host cell factor C2 -
Overview
This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. -
Synonyms
HCFC2;host cell factor C2;host cell factor 2;HCF 2;C2 factor;HCF2;HCF-2;FLJ94012
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Rat
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
HCFC2 involved in several pathways and played different roles in them. We selected most pathways HCFC2 participated on our site, such as Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCFC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | SRSF4,MAVS,SRSF2,STAT2,MHC1UEA,IRF3,NFKBIB,RNASEL,SKP2,IFNA14 |
Protein Function
HCFC2 has several biochemical functions, for example, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HCFC2 itself. We selected most functions HCFC2 had, and list some proteins which have the same functions with HCFC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | NR2F1,TADA3,GTF2A1,SOX10,BIRC2,SUPT3H,NACA,KAT6A,ARL2BP,MED21 |
Interacting Protein
HCFC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCFC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HCFC2.
KMT2A;MEN1;FOXO3;RBBP5;NUDCD3;SIRT1;ASH2L;ASH2L;NUDC;UTP18;capR;MYC;IRF2;PPP2R2B;ESR2;Set
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References
- Thompson-Crispi, KA; Sargolzaei, M; et al. A genome-wide association study of immune response traits in Canadian Holstein cattle. BMC GENOMICS 15:-(2014).
- Tsou, YL; Lin, YW; et al. Heat Shock protein 90: Role in Enterovirus 71 Entry and Assembly and Potential Target for Therapy. PLOS ONE 8:-(2013).
