HCAR2
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Official Full Name
hydroxycarboxylic acid receptor 2 -
Overview
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. -
Synonyms
HCAR2;hydroxycarboxylic acid receptor 2;HCA2;HM74a;HM74b;PUMAG;NIACR1;Puma-g;GPR109A;niacin receptor 1;nicotinic acid receptor;G protein-coupled receptor 109A;G-protein coupled receptor 109A;G protein-coupled receptor HM74a;G-protein coupled receptor HM74A;hydroxy-carboxylic acid receptor 2
Recombinant Proteins
- Human
- Mus musculus
- Rat
- HEK293
- HEK293T
- Mammalian cells
- E.coli expression system
- His&Fc&Avi
- Myc&DDK
- Flag
- His
Involved Pathway
HCAR2 involved in several pathways and played different roles in them. We selected most pathways HCAR2 participated on our site, such as cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCAR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | HCN4,CREB5,PTCH1,GHSR,PDE4A,NFKBIA,GRIN3A,LIPE,RAC2,ATP1A1 |
Protein Function
HCAR2 has several biochemical functions, for example, nicotinic acid receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HCAR2 itself. We selected most functions HCAR2 had, and list some proteins which have the same functions with HCAR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
HCAR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCAR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HCAR2.
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