HAO2
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Official Full Name
hydroxyacid oxidase 2 (long chain) -
Overview
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed predominantly in liver and kidney and has the highest activity toward the substrate 2-hydroxypalmitate. Two alternatively spliced variants encoding the same isoform have been described. -
Synonyms
HAO2;hydroxyacid oxidase 2 (long chain);hydroxyacid oxidase 2;(S) 2 hydroxy acid oxidase;GIG16;glycolate oxidase;growth inhibiting protein 16;HAOX2;long chain L 2 hydroxy acid oxidase;peroxisomal;(S)-2-hydroxy-acid oxidase;2 hydroxy acid oxidase peroxisomal;Cell growth-inhibiting gene 16 protein;HAO 2;HAOX2_HUMAN;Long chain alpha hydroxy acid oxidase;Long chain alpha-hydroxy acid oxidase;Long-chain L-2-hydroxy acid oxidase;growth-inhibiting protein 16;(S)-2-hydroxy-acid oxidase, peroxisomal
Recombinant Proteins
- Rat
- Zebrafish
- Human
- Mouse
- Mammalian Cells
- HEK293
- Wheat Germ
- E.coli
- In Vitro Cell Free System
- His
- Myc&DDK
- GST
- Non
- His&Fc&Avi
- His&SUMO
- Flag
Involved Pathway
HAO2 involved in several pathways and played different roles in them. We selected most pathways HAO2 participated on our site, such as Glyoxylate and dicarboxylate metabolism,Metabolic pathways,Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PGS1,ATP5A1,GLUD1A,ALPI.2,mt-Atp8,ATP6V0A1B,PYCRL,EARS2,PRIM2,NDUFB6 |
| Carbon metabolism | ALDOCA,DLD,SUCLG1,GPT2L,PFKL,GPT2,ALDOA,RPE,TPI1A,TKT |
| Glyoxylate and dicarboxylate metabolism | GLULC,AGXTB,DHDPSL,AGXT,GCSHB,PGP,HAO1,GLDC,SHMT1,HOGA1 |
| Peroxisome | ACSL1A,PXMP2,EPHX2,CRATA,PEX10,MVK,ACSL1B,ABCD2,FAR2,PHYH |
Protein Function
HAO2 has several biochemical functions, for example, (S)-2-hydroxy-acid oxidase activity,FMN binding,long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HAO2 itself. We selected most functions HAO2 had, and list some proteins which have the same functions with HAO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity | HAO1 |
| FMN binding | CREG2,NOS2A,NDOR1,MTRR,NOS1,TYW1,NOS2,NOS2B,CREG1,DHODH |
| receptor binding | CXADR,ADAM10,IL29,CNTFR,ICAM3,SRMS,STOML2,PVRL4,PTK2AA,INSL3 |
| medium-chain-(S)-2-hydroxy-acid oxidase activity | HAO1 |
| (S)-2-hydroxy-acid oxidase activity | HAO1 |
| very-long-chain-(S)-2-hydroxy-acid oxidase activity | HAO1 |
Interacting Protein
HAO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAO2.
p27958-pro_0000037576
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References
- Barawkar, DA; Bandyopadhyay, A; et al. Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain L-2-hydroxy acid oxidase. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22:4341-4347(2012).
- Barawkar, DA; Meru, A; et al. Potent and Selective Inhibitors of Long Chain L-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats. ACS MEDICINAL CHEMISTRY LETTERS 2:919-923(2011).
