GTF2H4
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Official Full Name
general transcription factor IIH, polypeptide 4, 52kDa -
Overview
General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene. -
Synonyms
GTF2H4;general transcription factor IIH, polypeptide 4, 52kDa;general transcription factor IIH, polypeptide 4 (52kD subunit);general transcription factor IIH subunit 4;TFB2;TFIIH;Basic transcription factor 2 52 kDa subunit;Basic transcription factor 52 kDa subunit;BTF2 p52;General transcription factor IIH polypeptide 4 52kDa;General transcription factor IIH polypeptide 4 52kDa subunit;General transcription factor IIH polypeptide 4 52kDa variant;General transcription factor IIH polypeptide 4;OTTHUMP00000029049;OTTHUMP00000164874;TF2H4_HUMAN;TFIIH basal transcription factor complex p52 subunit;TFIIH protein;TIFIIH;Transcription factor II H;Transcription factor IIH 52 kDa subunit
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Chicken
- Human
- Mouse
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GTF2H4-10294Z | Recombinant Zebrafish GTF2H4 | Mammalian Cells | Zebrafish | His |
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| GTF2H4-2008R | Recombinant Rhesus monkey GTF2H4 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| GTF2H4-2028C | Recombinant Chicken GTF2H4 | Mammalian Cells | Chicken | His |
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| GTF2H4-28282TH | Recombinant Human GTF2H4 | Wheat Germ | Human | Non | 100 amino acids |
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| GTF2H4-421H | Recombinant Human GTF2H4 Protein, His-tagged | E.coli | Human | His |
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| GTF2H4-4452H | Recombinant Human GTF2H4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GTF2H4-7361M | Recombinant Mouse GTF2H4 Protein | Mammalian Cells | Mouse | His |
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| GTF2H4-5694HCL | Recombinant Human GTF2H4 293 Cell Lysate | HEK293 | Human | Non |
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| GTF2H4-1829R | Recombinant Rhesus Macaque GTF2H4 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| GTF2H4-1829R-B | Recombinant Rhesus Macaque GTF2H4 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| GTF2H4-3389HF | Recombinant Full Length Human GTF2H4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 462 amino acids |
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| GTF2H4-3991M | Recombinant Mouse GTF2H4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| GTF2H4-3991M-B | Recombinant Mouse GTF2H4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
GTF2H4 involved in several pathways and played different roles in them. We selected most pathways GTF2H4 participated on our site, such as Basal transcription factors,Nucleotide excision repair,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GTF2H4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Basal transcription factors | GTF2A2,ERCC3,MNAT1,GTF2F1,GTF2I,TAF4B,GTF2F2B,TAF5,TBPL1,TAF13 |
| Viral carcinogenesis | UBE3A,H2-Q10,HIST1H4M,PIK3R3,MAD1L1,HIST1H4K,CCND2,PSMC1,MDM2,HIST1H4N |
| Nucleotide Excision Repair | COPS5,ERCC6,ERCC5,GTF2H2C_2,RFC5,INO80,INO80C,GTF2H3,CUL4A,INO80E |
Protein Function
GTF2H4 has several biochemical functions, for example, ATP-dependent DNA helicase activity,contributes_to DNA-dependent ATPase activity,contributes_to RNA polymerase II carboxy-terminal domain kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GTF2H4 itself. We selected most functions GTF2H4 had, and list some proteins which have the same functions with GTF2H4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP-dependent DNA helicase activity | RUVBL2,WRN,CHST13,DDX3X,DHX9,RECQL,G3BP1,CHD2,BLM,DDX11 |
| contributes_to protein kinase activity | GTF2H1,ERCC2,GTF2H2,ERCC3,GTF2H3 |
| double-stranded DNA binding | EGFR,DDX11,HLF,APTX,NKX2-8,TP73,CTNNB1,AKAP8,YBX1,ZNF638 |
| contributes_to DNA-dependent ATPase activity | GTF2H2,ERCC3,RBBP4,GTF2H3,ERCC2,MNAT1,BPTF,GTF2H1 |
| contributes_to RNA polymerase II carboxy-terminal domain kinase activity | ERCC3,ERCC2,GTF2H1,MNAT1,GTF2H3,GTF2H2 |
| protein binding | FBXO32,MRPL1,HOXB5,HLTF,RBM3,TSPAN15,BBS9,OBSCN,ADCY6,NRP1B |
| transcription factor activity, sequence-specific DNA binding | SIN3A,HMGA1B,BTBD8,CTBP1,HOXB5B,RUNX3,AATF,HSF5,MAFG,FOXE1 |
Interacting Protein
GTF2H4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GTF2H4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GTF2H4.
CDK7;Rpl35;GTF2H5
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References
- Kim, JY; Kim, JH; et al. Lack of association between GTF2H4 genetic variants and AERD development and FEV1 decline by aspirin provocation. INTERNATIONAL JOURNAL OF IMMUNOGENETICS 39:486-491(2012).
- Buch, SC; Diergaarde, B; et al. Genetic variability in DNA repair and cell cycle control pathway genes and risk of smoking-related lung cancer. MOLECULAR CARCINOGENESIS 51:E11-E20(2012).
