GSPT2
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Official Full Name
G1 to S phase transition 2 -
Overview
This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability. -
Synonyms
GSPT2;G1 to S phase transition 2;eukaryotic peptide chain release factor GTP-binding subunit ERF3B;eRF3b;FLJ10441;eukaryotic peptide chain release factor subunit 3b;GST2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GSPT2-4403H | Recombinant Human GSPT2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GSPT2-7321M | Recombinant Mouse GSPT2 Protein | Mammalian Cell | Mouse | His |
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| GSPT2-5721HCL | Recombinant Human GSPT2 293 Cell Lysate | HEK293 | Human | Non |
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| GSPT2-3331HF | Recombinant Full Length Human GSPT2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 628 amino acids |
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| GSPT2-3963M | Recombinant Mouse GSPT2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GSPT2-3963M-B | Recombinant Mouse GSPT2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
GSPT2 involved in several pathways and played different roles in them. We selected most pathways GSPT2 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSPT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA surveillance pathway | UPF3B,EIF4A3,PPP2R2A,PPP1CC,RNGTT,ETF1A,PPP2R2B,PNN,CPSF2,PABPC1L2A |
Protein Function
GSPT2 has several biochemical functions, for example, GTP binding,GTPase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSPT2 itself. We selected most functions GSPT2 had, and list some proteins which have the same functions with GSPT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CD2AP,CLDN18,DTX3,CNOT4,CCDC167,AURKAIP1,SYCE3,ARPC3,TPD52L2,RFX5 |
| translation release factor activity | MTRF1,ETF1,GSPT1L |
| poly(A) RNA binding | RBM12B,RPF2,MTHFSD,EIF4G3,STRBP,EXOSC7,SNW1,NUSAP1,MRPL22,MRPL9 |
| GTPase activity | TRIM23,RAC1,TUBA1L,MXB,EIF2S3,RHOU,GNAT1,RAB9B,SEPT4,RAB32 |
| GTP binding | TUBA1L,RAB5AA,LSG1,EHD2B,GIMAP3,RAB5AB,RP2,RAB7A,ADSSL,MMAA |
Interacting Protein
GSPT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSPT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSPT2.
PABPC1;UPF1;ETF1;Pabpc1;Etf1;SMG1
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References
- Li, M; Wang, J; et al. eRF3b, a Biomarker for Hepatocellular Carcinoma, Influences Cell Cycle and Phosphoralation Status of 4E-BP1. PLOS ONE 9:-(2014).
- Xiao, RL; Gao, Y; et al. Polypeptide chain release factor eRF3 is a novel molecular partner of survivin. CELL BIOLOGY INTERNATIONAL 37:359-369(2013).
