GRM6

  • Official Full Name

    glutamate receptor, metabotropic 6

  • Overview

    L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8.

  • Synonyms

    GRM6;glutamate receptor, metabotropic 6;metabotropic glutamate receptor 6;GPRC1F;mGlu6;MGLUR6;CSNB1B;DKFZp686H1993
Cat.# Product name Source (Host) Species Tag Protein Length Price
GRM6-679H Recombinant Human GRM6 Mammalian Cells Human His
GRM6-3080H Recombinant Human GRM6 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
GRM6-3080H-B Recombinant Human GRM6 Protein Pre-coupled Magnetic Beads HEK293 Human
GRM6-5369H Recombinant Human GRM6 Protein, GST-tagged Wheat Germ Human GST

    Involved Pathway

    GRM6 involved in several pathways and played different roles in them. We selected most pathways GRM6 participated on our site, such as Phospholipase D signaling pathway,Neuroactive ligand-receptor interaction,Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glutamatergic synapse PRKACB,PLA2G4F,PRKACG,PLA2G4C,GRIN2D,GLS2,GNB1,SLC1A3,PPP3R1,PLA2G4A
    Phospholipase D signaling pathway PIP5K1B,RRAS,PTGFR,KRAS,PLA2G4F,SHC2,PLCG2,Kitl,RAF1,PIK3R5
    Neuroactive ligand-receptor interaction AVPR1A,TAAR5,GNRHR4,NPY7R,SSTR2,GABRG2,S1PR5A,P2RX7,P2RY2,TAAR9

    Protein Function

    GRM6 has several biochemical functions, for example, G-protein coupled receptor activity,glutamate receptor activity,group III metabotropic glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM6 itself. We selected most functions GRM6 had, and list some proteins which have the same functions with GRM6. You can find most of the proteins on our site.

    Function Related Protein
    protein binding MEP1B,PCBP2,COL6A2,RNF185,EPHB1,HMMR,ZFP36,CHMP4C,IFNA2,MYD88
    G-protein coupled receptor activity TAAR10A,VMN2R116,GPR161,GPR75,TAAR13B,LPAR1,CCR6A,TAAR7F,HTR1D,OR5B2
    group III metabotropic glutamate receptor activity GRM6A,GRM7,GRM8,GRM6B,GRM4
    protein homodimerization activity HIF1AN,NFS1,LCN2,CREB3,RAP1GAP,APOA1BP,TCF3,RABEP1,STUB1,FLT3
    glutamate receptor activity GRM8,GRID2,GRIK3,GRM4,GRIK5,GRM5,GRM3,GRM7,GRM1,GRIA1

    Interacting Protein

    GRM6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRM6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRM6.

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