GRM5

  • Official Full Name

    glutamate receptor, metabotropic 5

  • Overview

    L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

  • Synonyms

    GRM5;glutamate receptor, metabotropic 5;mGlu5;GPRC1E;MGLUR5;metabotropic glutamate receptor 5;GRM5 variant 9;metabotropic glutamate receptor 5 variant F;metabotropic glutamate receptor 5 variant G;metabotropic glutamate receptor 5 variant H

Recombinant Proteins

  • Rat
  • Chicken
  • Human
  • Mammalian Cells
  • HEK293
  • Insect Cells
  • E.coli
  • Wheat Germ
  • His
  • Non
  • Flag
  • Avi
  • Fc
  • Myc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
GRM5-2717R Recombinant Rat GRM5 Protein Mammalian Cells Rat His
GRM5-5714C Recombinant Chicken GRM5 Mammalian Cells Chicken His
GRM5-5733HCL Recombinant Human GRM5 293 Cell Lysate HEK293 Human Non
GRM5-0501H Recombinant Human GRM5 Protein (P569-K678, E579A, N667Y, I669A, G675M, K679-A836, T742A, S753A), Flag, His tagged Insect Cells Human Flag&His P569-K678, E579A, N667Y, I669A, G675M, K679-A836, T742A, S753A
GRM5-1143HFL Recombinant Human GRM5 protein, His&Flag-tagged HEK293 Human Flag&His 1-1180 aa
GRM5-2371R Recombinant Rat GRM5 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
GRM5-2371R-B Recombinant Rat GRM5 Protein Pre-coupled Magnetic Beads HEK293 Rat
GRM5-2996H Recombinant Human GRM5 protein, His&Myc-tagged E.coli Human His&Myc 22-580aa
GRM5-5368H Recombinant Human GRM5 Protein, GST-tagged Wheat Germ Human GST

    Involved Pathway

    GRM5 involved in several pathways and played different roles in them. We selected most pathways GRM5 participated on our site, such as Calcium signaling pathway,Phospholipase D signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway PLCD1A,ERBB2,GRIN1A,PPIF,ITPR3,TMEM8C,AGTR1,CAMK2G1,HTR5A,ERBB3A
    Long-term potentiation RAF1,GRIN2D,RAP1A,MAPK1,PPP3CC,CAMK2D,PRKACA,GRIN2C,GRIA1,PPP1CB
    Retrograde endocannabinoid signaling GABRA2,GABRA3,PLCB4,PLCB3,GABRR1,GABRR3,GNG5,GABRA5,GABRA6,ABHD6
    Gap junction PRKG2,LPAR1,HRAS,KRAS,GRB2A,HTR2B,Adcy4,TUBB,PDGFB,PRKCG
    Glutamatergic synapse PLD1,GNGT2,PRKCB,GNG10,PLCB4,SLC1A3,GNAI3,GNG13,GNAI1,GRM2
    Huntingtons disease NDUFS5,DNAH6,VDAC2,COX4I2,ATP5H,ATP5E,TBPL2,UCP1,BDNF,REST
    Neuroactive ligand-receptor interaction GABRQ,FSHR,OPRD1,PTGER4B,ADORA1,EDNRBA,RXFP2A,ADRB2A,P2RX4B,F2RL2
    Phospholipase D signaling pathway DGKD,PIK3CD,PLCG1,SHC4,PIP5K1C,INS2,PIK3CB,RRAS2,Pdgfa&Pdgfb,PLA2G4C

    Protein Function

    GRM5 has several biochemical functions, for example, A2A adenosine receptor binding,G-protein coupled receptor activity,glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM5 itself. We selected most functions GRM5 had, and list some proteins which have the same functions with GRM5. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor activity EDNRAA,GPR176,GPRC5C,GPR133,GPR115,TAS2R118,HTR1AA,PTGER2B,V2RH14,TAAR14D
    glutamate receptor activity GRM8,GRM7,GRM4,GRM6,GRID2,GRM3,GRM2,GRIK5,GRIA1,GRM1

    Interacting Protein

    GRM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRM5.

    PRKCZ;PRKCD

    Resources

    Gene Families

    GPCRs Class C

    Research Area

    Alzheimer's Disease
    Diabetic Peripheral Neuropathy

    References

    • Dahm, L; Ott, C; et al. Seroprevalence of Autoantibodies against Brain Antigens in Health and Disease. ANNALS OF NEUROLOGY 76:82-94(2014).

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