GRIK3
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Official Full Name
glutamate receptor, ionotropic, kainate 3 -
Overview
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. -
Synonyms
GRIK3;glutamate receptor, ionotropic, kainate 3;glutamate receptor, ionotropic kainate 3;GLUR7;EAA5;Excitatory amino acid receptor 5;GLR 7;GLR7;GLU R7;GLUR 7;GluR 7a;GluR7a;Glutamate receptor 7;Glutamate receptor ionotropic kainate 3;GRIK 3;gluR-7;dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7))
Recombinant Proteins
- Rat
- Mouse
- Human
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GRIK3-2697R | Recombinant Rat GRIK3 Protein | Mammalian Cells | Rat | His |
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| GRIK3-7266M | Recombinant Mouse GRIK3 Protein | Mammalian Cells | Mouse | His |
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| GRIK3-2351R | Recombinant Rat GRIK3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GRIK3-2351R-B | Recombinant Rat GRIK3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GRIK3-3928M | Recombinant Mouse GRIK3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GRIK3-3928M-B | Recombinant Mouse GRIK3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GRIK3-5338H | Recombinant Human GRIK3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GRIK3-5644HF | Recombinant Full Length Human GRIK3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 919 amino acids |
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Involved Pathway
GRIK3 involved in several pathways and played different roles in them. We selected most pathways GRIK3 participated on our site, such as Neuroactive ligand-receptor interaction,Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutamatergic synapse | GRIN2A,GRM4,PRKCB,PLA2G4C,HOMER2,GNG4,Adcy4,HOMER3,PRKACA,PLCB4 |
| Neuroactive ligand-receptor interaction | LHBETA1,CHRNA6,S1PR2,CNR1,DRD4A,TAAR7D,ADORA2AA,CHRNB3,PRSS1,NPY2R |
Protein Function
GRIK3 has several biochemical functions, for example, adenylate cyclase inhibiting G-protein coupled glutamate receptor activity,extracellular-glutamate-gated ion channel activity,glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIK3 itself. We selected most functions GRIK3 had, and list some proteins which have the same functions with GRIK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ion channel activity | GRIA2A,ASIC4,P2RX3B,FXYD6L,TRPA1B,KCNH6A,P2RX3A,TRPM5,CLCN3,KCNS3A |
| protein binding | IRAK1,PPP1R2P9,WASL,COG1,ITGA1,BRCC3,ASMTL,CXXC11,RAB38,LSM2 |
| receptor activity | RTN4RL2,TNFRSF25,NOTCH1,CADM1A,MED1,VMN1R44,PAQR4,NRXN3,TNFRSF11A,UBXN6 |
| extracellular-glutamate-gated ion channel activity | GRIA3B,GRID2,GRIK4,GRIA2A,GRIN3B,GRIK1,GRIN3A,GRIN2C,GRIA4,GRIA2B |
| ionotropic glutamate receptor activity | GRIN2A,KBP,GRID1,GRIN1A,GRIN1B,GRIA4B,GRIA2A,GRIK5,GRID2,GRIA3B |
| kainate selective glutamate receptor activity | GRIK2,GRIK5,GRIK1,GRIK4 |
| glutamate receptor activity | GRM4,GRM1,GRIK5,GRM3,GRIA1,GRM2,GRM5,GRID2,GRM7,GRM8 |
Interacting Protein
GRIK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIK3.
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References
- Trippe, J; Steinke, K; et al. Autoantibodies to Glutamate Receptor Antigens in Multiple Sclerosis and Rasmussen's Encephalitis. NEUROIMMUNOMODULATION 21:189-194(2014).
- Balasuriya, D; Goetze, TA; et al. alpha-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid (AMPA) and N-Methyl-D-aspartate (NMDA) Receptors Adopt Different Subunit Arrangements. JOURNAL OF BIOLOGICAL CHEMISTRY 288:-(2013).
