GRIK2
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Official Full Name
glutamate receptor, ionotropic, kainate 2 -
Overview
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. -
Synonyms
GRIK2;glutamate receptor, ionotropic, kainate 2;GLUR6;glutamate receptor, ionotropic kainate 2;MRT6;gluR-6;bA487F5.1;OTTHUMP00000017949;OTTHUMP00000017950;OTTHUMP00000017951;glutamate receptor 6;glutamate receptor form A;glutamate receptor form B;glutamate receptor form C;glutamate receptor form D;glutamate recep;EAA4;GLR6;GLUK6
Recombinant Proteins
- Human
- Rat
- Mouse
- Xenopus laevis
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His&T7
- His
- Fc
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
- GST
Involved Pathway
GRIK2 involved in several pathways and played different roles in them. We selected most pathways GRIK2 participated on our site, such as Neuroactive ligand-receptor interaction,Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | GRIN3A,GRM1,TRY,ADCYAP1R1A,LPAR3,MLNR,GABBR2,GRIK3,MTNR1AA,GRIA4 |
| Glutamatergic synapse | GNAS,HOMER2,GNAQ,PRKCA,PRKACG,GLS2,SLC38A3,GRIN3A,GNG11,MAPK1 |
Protein Function
GRIK2 has several biochemical functions, for example, PDZ domain binding,extracellular-glutamate-gated ion channel activity,kainate selective glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIK2 itself. We selected most functions GRIK2 had, and list some proteins which have the same functions with GRIK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kainate selective glutamate receptor activity | GRIK3,GRIK5,GRIK4,GRIK1 |
| ubiquitin protein ligase binding | UBE2B,TMEM173,CUL4B,SMAD6,MC1R,POLR2A,UBE2N,GABARAPL2,PER3,CCDC50 |
| protein homodimerization activity | MAP3K11,PVALB,NOG,GSTZ1,NADKD1,APOA1BP,FGFR2,PEX11A,TENM2,VIL1 |
| PDZ domain binding | GNG12,SRR,GRM7,CFTR,FZD2,ATP2B3A,NKD1,CIT,SLC9A3,ATP2B1A |
| extracellular-glutamate-gated ion channel activity | GRIA2B,GRIN1,GRIA3A,GRIN3A,KBP,GRIA4A,GRIA3,GRIN3B,GRIA2A,GRIK3 |
| ubiquitin conjugating enzyme binding | RNF40,RNF19A,ZMYM2,RNF144AB,TCHP,RNF14,ARIH2,UBE2V1,DCUN1D2B,DCUN1D2 |
Interacting Protein
GRIK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIK2.
TRIM25;CALCOCO1
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References
- Shen, W; Hanley-Bowdoin, L; et al. Geminivirus infection up-regulates the expression of two Arabidopsis protein kinases related to yeast SNF1-and mammalian AMPK-activating kinases. PLANT PHYSIOLOGY 142:1642-1655(2006).
- PASCHEN, W; BLACKSTONE, CD; et al. HUMAN GLUR6 KAINATE RECEPTOR (GRIK2) - MOLECULAR-CLONING, EXPRESSION, POLYMORPHISM, AND CHROMOSOMAL ASSIGNMENT. GENOMICS 20:435-440(1994).
