GRHL3
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Official Full Name
grainyhead-like 3 (Drosophila) -
Overview
This gene encodes a member of the grainyhead family of transcription factors. The encoded protein may function as a transcription factor during development, and has been shown to stimulate migration of endothelial cells. Multiple transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
GRHL3;grainyhead-like 3 (Drosophila);TFCP2L4, transcription factor CP2 like 4;grainyhead-like protein 3 homolog;SOM;Drosophila;Grainyhead like 3;Grainyhead like protein 3 homolog;Sister of mammalian grainyhead protein;TFCP2L4;Transcription factor CP2 like 4;OTTHUMP00000003072;OTTHUMP00000003297;OTTHUMP00000003298;OTTHUMP00000234795;transcription factor hSOM1;sister of mammalian grainyhead;sister-of-mammalian grainyhead;transcription factor CP2-like 4
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Myc&DDK
- His&Fc&Avi
- GST
Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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GRHL3-13525H | Recombinant Human GRHL3, His-tagged | E.coli | Human | His | 206-556a.a. | |
GRHL3-7255M | Recombinant Mouse GRHL3 Protein | Mammalian Cell | Mouse | His |
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GRHL3-2367H | Recombinant Human GRHL3 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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Grhl3-3306M | Recombinant Mouse Grhl3 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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GRHL3-3922M | Recombinant Mouse GRHL3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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GRHL3-3922M-B | Recombinant Mouse GRHL3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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GRHL3-5221H | Recombinant Human GRHL3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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GRHL3-5327H | Recombinant Human GRHL3 Protein, GST-tagged | Wheat Germ | Human | GST |
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GRHL3-5618HF | Recombinant Full Length Human GRHL3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 555 amino acids |
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Involved Pathway
GRHL3 involved in several pathways and played different roles in them. We selected most pathways GRHL3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GRHL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Protein Function
GRHL3 has several biochemical functions, for example, chromatin DNA binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRHL3 itself. We selected most functions GRHL3 had, and list some proteins which have the same functions with GRHL3. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | ITM2A,ABHD1,IYD,FUNDC1,TBX2A,CCND2,MRPL53,SULT1A2,RANBP3,DPM1 |
chromatin DNA binding | H1F0,FOXC2,XBP1,NEUROG3,VAX2,THRB,HIST1H1A,HIST1H1C,BCL6,APEX1 |
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | STAG2,SOHLH1,MAFA,ARID3A,CSRNP2,MAFBB,GATA1A,LEF1,EAF2,SLAMF7 |
transcription factor activity, sequence-specific DNA binding | SIX1B,MNT,ZSCAN10,MYC,AHCTF1,RORAB,E2F2,ELK4,HSF5,FOXL1 |
sequence-specific DNA binding | EF1,Ar,HOXB8A,SOX6,VRTN,SFPI1,BCL11B,GBX1,FOXP4,ESRRB |
Interacting Protein
GRHL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRHL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRHL3.
PRMT5;PRMT6;PRMT1
Resources
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References
- Gordon, WM; Zeller, MD; et al. A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia. JOURNAL OF CLINICAL INVESTIGATION 124:5205-5218(2014).
- Pourhoseini, S; Seth, RK; et al. Upregulation of miR21 and Repression of Grhl3 by Leptin Mediates Sinusoidal Endothelial Injury in Experimental Nonalcoholic Steatohepatitis. PLOS ONE 10:-(2015).