GRHL2
-
Official Full Name
grainyhead-like 2 (Drosophila) -
Overview
The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28). -
Synonyms
GRHL2;grainyhead-like 2 (Drosophila);deafness, autosomal dominant 28 , DFNA28, TFCP2L3, transcription factor CP2 like 3;grainyhead-like protein 2 homolog;BOM;FLJ13782;DFNA28;FLJ11172;MGC149294;TFCP2L3;Brother of mammalian grainyhead;Deafness autosomal dominant 28;Grainyhead like 2 (Drosophila);Grainyhead like 2;Grainyhead like protein 2 homolog;GRHL 2;MGC149295;Transcription factor CP2 like 3;transcription factor CP2-like 3
Recombinant Proteins
- Mouse
- Human
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GRHL2-7254M | Recombinant Mouse GRHL2 Protein | Mammalian Cells | Mouse | His |
|
|
| GRHL2-5750HCL | Recombinant Human GRHL2 293 Cell Lysate | HEK293 | Human | Non |
|
|
| Grhl2-3305M | Recombinant Mouse Grhl2 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
|
|
| GRHL2-3921M | Recombinant Mouse GRHL2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| GRHL2-3921M-B | Recombinant Mouse GRHL2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| GRHL2-4285H | Recombinant Human GRHL2 protein, His-tagged | E.coli | Human | His | 1-625aa |
|
| GRHL2-5326H | Recombinant Human GRHL2 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| GRHL2-5327H | Recombinant Human GRHL2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
|
| GRHL2-5612HF | Recombinant Full Length Human GRHL2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 625 amino acids |
|
Involved Pathway
GRHL2 involved in several pathways and played different roles in them. We selected most pathways GRHL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GRHL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
GRHL2 has several biochemical functions, for example, chromatin DNA binding,intronic transcription regulatory region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRHL2 itself. We selected most functions GRHL2 had, and list some proteins which have the same functions with GRHL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | PKNOX1,ATF5,ALX1,ONECUT3,NEUROD2,FOXF2,CREB3L3,ETV5,MAFGB,NHLH1 |
| transcription factor activity, sequence-specific DNA binding | HOXA13,FOXN2,ZNF493,HIST1H2AH,TCF4,LHX8A,HOXC6,HES1,FOXD3,MECOM |
| protein binding | KAL1,KRTAP10-9,ANKRA2,DYNLL1,LGR5,POR,SRSF1,FBXO25,THAP6,GATAD2B |
| intronic transcription regulatory region sequence-specific DNA binding | BCL6,NKX2-1 |
| chromatin DNA binding | AASS,FOXC2,THRB,H2AFY,HIST1H1C,VAX2,GRHL3,CLOCK,ACTN4,EP300 |
| sequence-specific DNA binding | FOXC2,HOXA4,IRX3B,RBPJ,HOXA11,NKX1.2LA,HLFB,NR4A2A,PBX1A,FOXI3B |
Interacting Protein
GRHL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRHL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRHL2.
LMO4
Resources
Related Services
Related Products
References
- Singh, B; Shamsnia, A; et al. Highly Adaptable Triple-Negative Breast Cancer Cells as a Functional Model for Testing Anticancer Agents. PLOS ONE 9:-(2014).
- Tanimizu, N; Kobayashi, S; et al. Downregulation of miR122 by grainyhead-like 2 restricts the hepatocytic differentiation potential of adult liver progenitor cells. DEVELOPMENT 141:4448-4456(2014).
