GRAP
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Official Full Name
GRB2-related adaptor protein -
Overview
This gene encodes a member of the GRB2/Sem5/Drk family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. -
Synonyms
GRAP;GRB2-related adaptor protein;GRB2-related adapter protein;GRB2 related adaptor protein;Growth factor receptor bound protein 2 related adaptor protein;MGC64880;OTTHUMP00000065766;growth factor receptor-bound protein 2-related adaptor protein
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
GRAP involved in several pathways and played different roles in them. We selected most pathways GRAP participated on our site, such as Kit Receptor Signaling Pathway,Signal Transduction,Signaling by SCF-KIT, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Kit Receptor Signaling Pathway | DOK1B,GRB10,GRB7,DOK1,PTPRU,GRAPA,SOCS4,SPRED2B,PTPRUB,STAP1 |
| Signal Transduction | NOXA1,NOXO1,NOTUM1A,TMED5,MDKA,ARHGAP4A,CXCR7B,FSTL1,KREMEN2,RAB6A |
| Signaling by SCF-KIT | SH2B3,PTPRUB,PTPRU |
Protein Function
GRAP has several biochemical functions, for example, SH3/SH2 adaptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRAP itself. We selected most functions GRAP had, and list some proteins which have the same functions with GRAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FAM109B,KREMEN1,TTC1,DPYSL4,PRRC1,ZNF593,GLI2,INHA,EFCAB4A,GPR128 |
| SH3/SH2 adaptor activity | GRB2,ITSN2,BLNK,PAG1,NCK2,SLA,SH3BGRL,LAT,GAB1,FCRL2 |
Interacting Protein
GRAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRAP here. Most of them are supplied by our site. Hope this information will be useful for your research of GRAP.
TRIM21;RBPMS;dapD;BCR;SHC1
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References
- Vazquez, DS; Agudelo, WA; et al. A helix-coil transition induced by the metal ion interaction with a grafted iron-binding site of the CyaY protein family. DALTON TRANSACTIONS 44:2370-2379(2015).
- Su, HY; Chen, CC; et al. A Novel Fast Layout Encoding Method for Exact Multilayer Pattern Matching With Prufer Encoding. IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS 34:95-108(2015).
