GPRC6A
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Official Full Name
G protein-coupled receptor, family C, group 6, member A -
Overview
G protein-coupled receptor family C group 6 member A is a protein that in humans is encoded by the GPRC6A gene. This receptor functions as a sensor of L-amino acids, calcium, osteocalcin, and steroids. -
Synonyms
GPRC6A;G protein-coupled receptor, family C, group 6, member A;G-protein coupled receptor family C group 6 member A;bA86F4.3;hGPCR33;hGPRC6A;predicted with SOSUI analysis;G-protein coupled receptor GPCR33;seven transmembrane helix receptor;GPCR
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mammalian Cell
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GPRC6A-1193H | Recombinant Human GPRC6A | Mammalian Cell | Human | His |
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| GPRC6A-1941Z | Recombinant Zebrafish GPRC6A | Mammalian Cell | Zebrafish | His |
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| GPRC6A-2673R | Recombinant Rat GPRC6A Protein | Mammalian Cell | Rat | His |
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| GPRC6A-5769HCL | Recombinant Human GPRC6A 293 Cell Lysate | HEK293 | Human | Non |
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| GPRC6A-01H | Recombinant Human GPRC6A Protein, His-Tagged | E.coli | Human | His |
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| GPRC6A-2327R | Recombinant Rat GPRC6A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GPRC6A-2327R-B | Recombinant Rat GPRC6A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GPRC6A-3072H | Recombinant Human GPRC6A Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| GPRC6A-3072H-B | Recombinant Human GPRC6A Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
GPRC6A involved in several pathways and played different roles in them. We selected most pathways GPRC6A participated on our site, such as Class C/3 (Metabotropic glutamate/pheromone receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPRC6A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | TAS2R3,TAS2R13,TAS2R7,TAS2R16,CASR |
| Signal Transduction | OXGR1A.2,BBS13,PENK,RPE65A,SDR9C7,EMR2,INHBAA,CRABP2A,HEBP1,FSTL3 |
| GPCR downstream signaling | VIP2,APLNR,ARHGEF16,CYSLTR1,TAS2R16,OR52B4,OPN5,NPFF,INSL5,DRD4 |
| GPCR ligand binding | PROKR1,OXER1,GPR132,PENK,OXGR1A.3,OPN4B,OPN1MW,FZD10,ADM2,CNR2 |
| Signaling by GPCR | TAS2R3,OXGR1,PTHLH,CD97,TAS2R16,OR56A1,ANXA1B,PTHLHA,SST1.1,MLN |
| Gastrin-CREB signalling pathway via PKC and MAPK | PRKCHB,TRIO,NPFFR2,CASR,ANXA1B,NMB,LPAR1,NPSR1,OXTRL,PROKR2 |
| G alpha (q) signalling events | NTS,FFAR3,RGS18,ANXA1A,FPR-RS4,HCRT,APPB,RASGRP2,PROK1,DGKA |
Protein Function
GPRC6A has several biochemical functions, for example, G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPRC6A itself. We selected most functions GPRC6A had, and list some proteins which have the same functions with GPRC6A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | TAAR12F,OR4D2,CCR10,OR2L2,TMTOPS2B,GPR110,CXCR5,GPR50,GPR39,GPR35 |
Interacting Protein
GPRC6A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPRC6A here. Most of them are supplied by our site. Hope this information will be useful for your research of GPRC6A.
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References
- De Toni, L; De Filippis, V; et al. Uncarboxylated Osteocalcin Stimulates 25-Hydroxy Vitamin D Production in Leydig Cell Line Through a GPRC6a-Dependent Pathway. ENDOCRINOLOGY 155:4266-4274(2014).
- Harno, E; Edwards, G; et al. Evidence for the presence of GPRC6A receptors in rat mesenteric arteries. CELL CALCIUM 44:210-219(2008).
