GPR4
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Official Full Name
G protein-coupled receptor 4 -
Overview
G-protein coupled receptor 4 is a protein that in humans is encoded by the GPR4 gene. -
Synonyms
GPR4;G protein-coupled receptor 4;G-protein coupled receptor 4;G-protein coupled receptor 19
Recombinant Proteins
- Human
- Rat
- Mouse
- Bovine
- Sus scrofa (Pig)
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Avi
- Fc
- Non
Involved Pathway
GPR4 involved in several pathways and played different roles in them. We selected most pathways GPR4 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | INSL3,RIT1,ARHGAP40,MYO9B,TAC2,KDM4C,PPEF1,DCLRE1B,NRP2A,UTS2D |
| Gastrin-CREB signalling pathway via PKC and MAPK | ARHGEF25,GCGA,TRPC3,LTB4R,LPAR2B,NPSR1,PROK1,OXTRL,OPN4B,FPR-RS4 |
| GPCRs, Class A Rhodopsin-like | PTGDR2,CCR1,GPR77,AGTR2,OPN1MW,DRD4,DRD3,ADORA3,GPR6,LTB4R |
| GPCR ligand binding | FPR-RS4,GPR31B,QRFPR,RLN3,GPR31,RLN3A,S1PR5B,FFAR3,GPR39,CCL35.2 |
| Signaling by GPCR | SOUL4,RAMP2,PROK2,PTH,INSL5,TAAR1,RCA2.1,NMBA,GPR31B,GPR37L1 |
| G alpha (q) signalling events | FPR-RS6,TRH,NTS,OPN4,TAC1,PROK2,GRP,DGKB,QRFP,AGT |
| GPCR downstream signaling | CHRM3,NTS,ADORA1,GPR68,CRHB,OXGR1A.1,ARHGAP4,OPN5,AMCF-II,OPN1SW1 |
| Class A/1 (Rhodopsin-like receptors) | ADRB2,CCK,GPR77,PNOCB,PROKR1A,ADRB3,RXFP2,OPN1LW1,AGTR1,ADRA2A |
Protein Function
GPR4 has several biochemical functions, for example, G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPR4 itself. We selected most functions GPR4 had, and list some proteins which have the same functions with GPR4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | GRM6B,RXFP3.2B,TAAR13C,GPRC5D,TAAR8A,TAS2R200.2,DRD4A,HCRTR1,MRGPRH,OR6Q1 |
Interacting Protein
GPR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPR4.
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References
- Mochimaru, Y; Azuma, M; et al. Extracellular acidification activates ovarian cancer G-protein-coupled receptor 1 and GPR4 homologs of zebra fish. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 457:493-499(2015).
- Lu, ZY; Gui, HB; et al. Short-chain fatty acids and acidic pH upregulate UT-B, GPR41, and GPR4 in rumen epithelial cells of goats. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 308:R283-R293(2015).
