GPR27
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Official Full Name
G protein-coupled receptor 27 -
Overview
GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, May 2010] -
Synonyms
GPR27;G protein-coupled receptor 27;SREB1;probable G-protein coupled receptor 27;super conserved receptor expressed in brain 1
Recombinant Proteins
- Rat
- Zebrafish
- Mouse
- Human
- Mus musculus
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- His&Fc&Avi
- Non
Involved Pathway
GPR27 involved in several pathways and played different roles in them. We selected most pathways GPR27 participated on our site, such as GPCRs, Class A Rhodopsin-like,Odorant GPCRs, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPR27 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Odorant GPCRs | LGR4,VMN1R45,VMN1R46,GPR141,GPR82,GPR108,VMN1R40,MRGPRB2,GPR173,VMN1R41 |
| GPCRs, Class A Rhodopsin-like | GPR45,ADORA1,GPR68,PTGDR2,GPR39,SSTR1,CCR9,AGTR2,CX3CR1,SSTR3 |
Protein Function
GPR27 has several biochemical functions, for example, G-protein coupled receptor activity,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPR27 itself. We selected most functions GPR27 had, and list some proteins which have the same functions with GPR27. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | OR2A4,OLFR958,BAI3,LANCL1,PTGER4A,OLFR498,GPR183,V1RA8,NPFFR1L1,CCR1L1 |
| signal transducer activity | SLC35B2,RGS9A,BMX,Fzd4,TAAR14G,GNAI3,GNGT2A,PLCZ1,GNG3,AGTR1B |
Interacting Protein
GPR27 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPR27 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPR27.
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References
- Petrich, A; Mann, A; et al. Phosphorylation of Threonine 333 Regulates Trafficking of the Human sst(5) Somatostatin Receptor. MOLECULAR ENDOCRINOLOGY 27:671-682(2013).
- Pierce, M; Sandrock, R; et al. Measurement of thyroid stimulating immunoglobulins using a novel thyroid stimulating hormone receptor-guanine nucleotide-binding protein, (GNAS) fusion bioassay. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 170:115-121(2012).
