GPR119
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Official Full Name
G protein-coupled receptor 119 -
Synonyms
GPR119;G protein-coupled receptor 119;glucose-dependent insulinotropic receptor;GPCR2;hGPCR2;G-protein coupled receptor 2;G-protein coupled receptor 119;MGC119957
Recombinant Proteins
- Rat
- Mouse
- Human
- Mus musculus
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
GPR119 involved in several pathways and played different roles in them. We selected most pathways GPR119 participated on our site, such as Incretin synthesis, secretion, and inactivation,Insulin secretion,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPR119 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin secretion | PLCB1,SNAP25,RYR2,ATP1A4,PCLO,INS2,FXYD2,ATP1B4,ATP1A1,CAMK2D |
| Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | DPP4,PCSK1 |
| Peptide hormone metabolism | SLC38A8,CPA3,BCHE,PCSK2,GPR120,CPB2,MBOAT4,SLC30A6,SPCS3,INHA |
| Incretin synthesis, secretion, and inactivation | GRP,DPP4,SPCS3,O3far1,PCSK1,GPR120,SLC38A8,CDX2 |
| Metabolism of proteins | FKBP9,MUC13,SLC35A1,FBXL5,CCT7,TBCC,LMCD1,HSCB,SLC25A12,MUC12 |
| cAMP signaling pathway | BDNF,AKT2,VIPR2,GRIA4,CNGA2,GPR81,RRAS2,GLI1,PDE3A,CAMK2A |
Protein Function
GPR119 has several biochemical functions, for example, G-protein coupled receptor activity,phosphatidylcholine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPR119 itself. We selected most functions GPR119 had, and list some proteins which have the same functions with GPR119. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | GPR6,OPN1MW2,OLFR688,TACR3A,GRM2A,OR51B2,GPR116,PROKR1,CHRM5B,TAS2R200.1 |
| phosphatidylcholine binding | APOA1A,ALDOB,APOA4B.1,CHMP3,PCTP,APOA2,APOA5,RASGRP1,NF1,APOA1 |
Interacting Protein
GPR119 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPR119 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPR119.
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References
- Cornall, LM; Hryciw, DH; et al. Direct activation of the proposed anti-diabetic receptor, GPR119 in cardiomyoblasts decreases markers of muscle metabolic activity. MOLECULAR AND CELLULAR ENDOCRINOLOGY 402:72-85(2015).
- Engelstoft, MS; Norn, C; et al. Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119. BRITISH JOURNAL OF PHARMACOLOGY 171:5774-5789(2014).
