GP5
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Official Full Name
glycoprotein V (platelet) -
Overview
Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010] -
Synonyms
GP5;glycoprotein V (platelet);GPV;CD42d;platelet glycoprotein V;glycoprotein 5
Recombinant Proteins
- Human
- Mouse
- Rat
- Mus musculus
- Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)
- E.coli
- Mammalian Cells
- HEK293
- His
- T7
- Avi
- Fc
Involved Pathway
GP5 involved in several pathways and played different roles in them. We selected most pathways GP5 participated on our site, such as ECM-receptor interaction,Platelet activation,Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with GP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hematopoietic cell lineage | CSF1R,CD22,CD1E,IL1R1,CSF3,IL4R,CSF3R,THPO,CD3G,FCER2 |
| ECM-receptor interaction | COL2A1,COL4A6,ITGB5,LAMA2,COL6A2,ITGA11A,LAMB1A,LAMC3,ITGAV,ITGB3 |
| Platelet activation | MYL12B,GUCY1B3,ITGA2,RAP1B,ARHGAP35,STIM1,MAPK3,PPP1CA,GNAI2,ORAI1 |
Protein Function
GP5 has several biochemical functions, for example, collagen binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GP5 itself. We selected most functions GP5 had, and list some proteins which have the same functions with GP5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| collagen binding | ACHE,MMP13,MMP9,VWF,SMAD4,GPR56,SERPINH2,ADAM9,COMP,MRC2 |
| protein binding | PCMT1,DNAJC19,GRIN2B,AP2B1,Ar,C17orf82,EMD,ANO2,DPH2,BCL10 |
Interacting Protein
GP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GP5.
GP9
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References
- Yu, Y; Wang, G; et al. Single-chain anti-idiotypic antibody retains its specificity to porcine reproductive and respiratory syndrome virus GP5. IMMUNOLOGY LETTERS 163:8-13(2015).
- Bao, LD; Si, Q; et al. Detection of human papillomavirus and expression of osteopontin in cervical cancer specimens. MOLECULAR MEDICINE REPORTS 11:447-453(2015).
