GNPTAB
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Official Full Name
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -
Overview
This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA. -
Synonyms
GNPTAB;N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits;GNPTA;N-acetylglucosamine-1-phosphotransferase subunits alpha/beta;KIAA1208;MGC4170;EC=2.7.8.17;GlcNAc-1-phosphotransferase subunits alpha/beta;GNPTA_HUMAN;N-acetylglucosamine-1-phosphotransferase subunit beta;Stealth protein GNPTAB;UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta;GlcNAc phosphotransferase;UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosamine;glucosamine (UDP-N-acetyl)-lysosomal-enzyme N-acetylglucosamine phosphotransferase;ICD
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GNPTAB-3916Z | Recombinant Zebrafish GNPTAB | Mammalian Cells | Zebrafish | His |
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| GNPTAB-7053M | Recombinant Mouse GNPTAB Protein | Mammalian Cells | Mouse | His |
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| GNPTAB-3785M | Recombinant Mouse GNPTAB Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GNPTAB-3785M-B | Recombinant Mouse GNPTAB Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| RFL17649MF | Recombinant Full Length Mouse N-Acetylglucosamine-1-Phosphotransferase Subunits Alpha/Beta(Gnptab) Protein, His-Tagged | E.coli | Mus musculus | His | Full L. Full Length of Mature Protein (908-1235) |
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| RFL18454DF | Recombinant Full Length Danio Rerio N-Acetylglucosamine-1-Phosphotransferase Subunits Alpha/Beta(Gnptab) Protein, His-Tagged | E.coli | zebrafish | His | Full L. Full Length of Mature Protein (894-1219) |
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Involved Pathway
GNPTAB involved in several pathways and played different roles in them. We selected most pathways GNPTAB participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNPTAB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | GLB1,HGSNAT,Abca2,SUMF1,PPT2,ABCB9,CTSH,SMPD1,GALNS,SLC17A5 |
Protein Function
GNPTAB has several biochemical functions, for example, UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity,calcium ion binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNPTAB itself. We selected most functions GNPTAB had, and list some proteins which have the same functions with GNPTAB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | GATA4,CD34,TFAP2A,INSIG2,SOX8,DIP2BA,MYC,FOXA1,NLK,UBN1 |
| metal ion binding | ZFAND5B,ZNF280D,TNKS2,PLA2G4F,ATP2C2,ZNF200,ZNF227,ZFP30,LMO4B,SALL4 |
| transferase activity | CDKN1D,NUCKS1A,LMTK3,HYKK.2,UGT8A,GSTT1B,DCLK2,NDUFAF6,SPTLC3,ELOVL4A |
| transferase activity, transferring phosphorus-containing groups | CKBA,CKMT1,CKBB,CKMT2A,CKMA,CKMB,CKMT2B |
| UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity | GNPTG |
| calcium ion binding | MMP14A,VCANB,CCDC167,Npnt,PCDHAC2,MMP16,C1R,PLS3,CIB1,S100A5 |
Interacting Protein
GNPTAB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNPTAB here. Most of them are supplied by our site. Hope this information will be useful for your research of GNPTAB.
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References
- Chen, H; Xu, JQ; et al. Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population. BMC GENETICS 16:-(2015).
- Qian, Y; van Meel, E; et al. Analysis of Mucolipidosis II/III GNPTAB Missense Mutations Identifies Domains of UDP-GlcNAc: lysosomal Enzyme GlcNAc-1-phosphotransferase Involved in Catalytic Function and Lysosomal Enzyme Recognition. JOURNAL OF BIOLOGICAL CHEMISTRY 290:3045-3056(2015).
