GNL3L
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Official Full Name
guanine nucleotide binding protein-like 3 (nucleolar)-like -
Overview
The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
GNL3L;guanine nucleotide binding protein-like 3 (nucleolar)-like;guanine nucleotide-binding protein-like 3-like protein;FLJ10613;novel GTPase;RP11-353K22.1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&SUMO
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GNL3L-13371H | Recombinant Human GNL3L, GST-tagged | E.coli | Human | GST | C-term-348a.a. | |
| GNL3L-7047M | Recombinant Mouse GNL3L Protein | Mammalian Cell | Mouse | His |
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| GNL3L-863Z | Recombinant Zebrafish GNL3L | Mammalian Cell | Zebrafish | His |
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| GNL3L-297HCL | Recombinant Human GNL3L lysate | HEK293 | Human | Non |
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| GNL3L-1121H | Recombinant Human GNL3L Protein (1-582 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 1-582 aa |
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| GNL3L-3780M | Recombinant Mouse GNL3L Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GNL3L-3780M-B | Recombinant Mouse GNL3L Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GNL3L-5083H | Recombinant Human GNL3L Protein, GST-tagged | Wheat Germ | Human | GST |
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| GNL3L-5398HF | Recombinant Full Length Human GNL3L Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 582 amino acids |
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Involved Pathway
GNL3L involved in several pathways and played different roles in them. We selected most pathways GNL3L participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNL3L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome biogenesis in eukaryotes | CSNK2A2A,NHP2,NXF1,NOP58,RNASEN,XRN2,WDR75,SBDS,PWP2H,RBM28 |
Protein Function
GNL3L has several biochemical functions, for example, GTP binding,GTPase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNL3L itself. We selected most functions GNL3L had, and list some proteins which have the same functions with GNL3L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | CCT6A,MRPL54,YARS2,BAG4,STRBP,ABCF1,SUMO2,S100A16,RRP1,RPL37A |
| protein binding | NUP62CL,ZNF830,THAP3,MEF2A,TPX2,STX4,CNBP,TFDP2,PPP1R13L,BNIP3 |
| GTP binding | ARF3,TPX2,TUBG2,SEPT4A,RHOA,FPGT,GPN2,RND3A,RHOF,RAB2B |
| GTPase activity | RAB6C,RRAD,GNL3,RHOT1A,EEF2A.1,RAB18A,RAB3AB,GNB1,MFN1B,ARF6 |
Interacting Protein
GNL3L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNL3L here. Most of them are supplied by our site. Hope this information will be useful for your research of GNL3L.
ALAS1;MDM2;LZTS2;ROPN1;TP53;LDOC1
Resources
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References
- Lin, T; Meng, LJ; et al. Nucleostemin and GNL3L exercise distinct functions in genome protection and ribosome synthesis, respectively. JOURNAL OF CELL SCIENCE 127:2302-2312(2014).
- Essers, PB; Pereboom, TC; et al. A comparative study of nucleostemin family members in zebrafish reveals specific roles in ribosome biogenesis.. DEVELOPMENTAL BIOLOGY 385:304-315(2014).
