GNAZ
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Official Full Name
guanine nucleotide binding protein (G protein), alpha z polypeptide -
Overview
The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids -
Synonyms
guanine nucleotide-binding protein G(z) subunit alpha;gz-alpha;g(x) alpha chain;transducin alpha;OTTHUMP00000197927;GNAZ;G Alpha x/z (C terminal)
Recombinant Proteins
- Rhesus macaque
- Human
- Rat
- Mouse
- Mammalian Cell
- E.coli
- Wheat Germ
- Insect Cell
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&GST
- His&Fc&Avi
- His&SUMO
Involved Pathway
GNAZ involved in several pathways and played different roles in them. We selected most pathways GNAZ participated on our site, such as Long-term depression, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Long-term depression | MAP2K1,PLCB3,PLA2G4A,PPP2R1B,LYN,PLA2G4C,CRHR1,GRIA1,KRAS,PPP2CB |
Protein Function
GNAZ has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding,G-protein coupled serotonin receptor binding,GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAZ itself. We selected most functions GNAZ had, and list some proteins which have the same functions with GNAZ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor signaling protein activity | BAG4,FCAR,CD19,IFITM1,FLRT3,RGS14,IL1RL1,BAG1,CD3E,FCGR1A |
| GTPase activity | ADSSL1,GNA11,MXC,RAB5AA,TUBA3D,GNG5,RAC1,RAB5C,RAB3DA,CDC42 |
| metal ion binding | ARSJ,OAS3,ZNF606,RASAL1,A3GALT2,BTR12,ZDHHC24,ZNF445,ANG3,NUBP2 |
| G-protein coupled serotonin receptor binding | GNAO1,GNAIA,GNAI3,GNAO1B,GNAO1A,GNAI1 |
| GTP binding | RHOJ,RAB5AA,GLUD1,GNAIA,RHOF,TUBB1,NRAS,RRAD,RIT1,SEPT5A |
| G-protein beta/gamma-subunit complex binding | GNAT3,GNAO1A,GNAI3,GNA11,CETN4,GNAS,GNA11A,GNA13,GNAI2,GNAO1B |
| signal transducer activity | TAS2R109,HCAR1-2,TAS2R138,AGTR1A,MTNR1C,PTH1RB,STAT1A,PLCG2,GNG13A,CANT1 |
Interacting Protein
GNAZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAZ here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAZ.
LRRK1;a8k1f4_human;STIP1;MLF1;PSMD2;NUDCD3;q96be0_human;AARSD1;CACYBP;FKBPL;HTT
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References
- Jin, SY; Martinelli, DC; et al. Gas1 is a receptor for sonic hedgehog to repel enteric axons. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E73-E80(2015).
- Hultman, R; Kumari, U; et al. G alpha z regulates BDNF-induction of axon growth in cortical neurons. MOLECULAR AND CELLULAR NEUROSCIENCE 58:53-61(2014).
