GNAI3
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Official Full Name
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -
Overview
Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 genel cellular processes. Three alternatively spliced variants have been described. -
Synonyms
87U6;FLJ26559;guanine nucleotide-binding protein G(k) subunit alpha;g(i) alpha-3;OTTHUMP00000013368;GNAI3
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
GNAI3 involved in several pathways and played different roles in them. We selected most pathways GNAI3 participated on our site, such as Rap signaling pathway,cGMP-PKG signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAI3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid signaling pathway | PRKCZ,MAPK1,PPP2R1B,MAPK3,ACER1,MAPK12,SPTLC3,MAPK9,GNAI2,SGMS2 |
| Gap junction | MAP3K2,MAP2K1,PRKCB,PRKACBB,TUBA8,PRKACAA,TUBB5,GJD2,CX35B,KRAS |
| Pathways in cancer | PRKCA,WNT6,WNT9B,GLI1,FADD,Fgf15,TCEB1,EGLN2,CXCL12,SPI1 |
| Retrograde endocannabinoid signaling | MAPK1,GABRG1,GABRG2,MAPK10,GABRR3,ITPR3,GABRA3,PTGS2,GNG3,PLCB1 |
| Cholinergic synapse | GNG4,CAMK4,PIK3CA,PIK3R1,PIK3CG,PIK3CB,CHRNB2,CAMK2D,KCNQ3,GNB4 |
| Serotonergic synapse | GNG4,PLA2G4C,CYP2C38,HTR3E,PLA2G4A,PRKACB,MAOB,GNAO1,GNB1,GNG5 |
| Axon guidance | NFATC2,NRAS,AP2A1,NCK1,RASGEF1A,GFRA4,CRMP1,RND1L,RND1,RGMA |
| Tight junction | MPP5A,PARD6GA,MYL10,CSDA,CLDN17,JAM2A,CLDN19,CLDNH,CLDN6,VMHCL |
| cGMP-PKG signaling pathway | ATP1B4,PIK3CD,CREB5,PRKG1,KCNMB4,Adcy4,RHOA,MAPK3,PRKCE,ATP1B2 |
Protein Function
GNAI3 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding,G-protein coupled serotonin receptor binding,GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAI3 itself. We selected most functions GNAI3 had, and list some proteins which have the same functions with GNAI3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signal transducer activity | GPR173,TRHR2,FST,GPR89,SH2B1,TAS2R123,PLCB2,TAAR14I,RHOC,SUFU |
| protein domain specific binding | WNT1,HIST1H4N,PRKCZ,HIST1H4I,HIST1H4B,HGS,STRN4,SCAF1,LIN7B,HIST1H4C |
| GTPase activating protein binding | GNAI1,CDH1,RGS14,GNAO1,MEX3B,TUBB,TSC1,GAPVD1,PTBP3,PLCD1 |
| G-protein beta/gamma-subunit complex binding | CETN4,GNA13A,GNA13,GNAQ,GNAO1A,GNA15.4,CETN2,GNAT2,GNA11,GNAL |
| GTPase activity | RAB42A,GTPBP2,DIRAS1,RAB10,RAB12,OPA1,RAB40B,EFTUD1,RHOB,LSG1 |
| GTP binding | SRPRB,RAB8A,RHOBTB1,RALB,IFT22,EIF5B,SEPHS1,MTG1,EEF1A1B,ARF6B |
| metal ion binding | ZC3H13,ZFYVE16,CAR6,ZNF323,ITGB1BP3,SMAD9,TRIM108,RPAP2,BCL11B,ITGA7 |
| protein binding | NFIX,PIH1D2,MEIS1B,PPP2R5C,USP4,BLOC1S6,PPP2R5A,CRBN,APBB3,IKZF1 |
| G-protein coupled serotonin receptor binding | GNAZ,GNAO1A,GNAI1,GNAIA,GNAO1B,GNAO1 |
Interacting Protein
GNAI3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAI3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAI3.
RGS17;GPSM3;GNG3;Cbx1;Cep76;Recql4;Trim69;Haus4;Haus1;Mical3;MAP3K3;Mau2;TRAF6
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References
- Tavares, VLR; Gordon, CT; et al. Novel variants in GNAI3 associated with auriculocondylar syndrome strengthen a common dominant negative effect. EUROPEAN JOURNAL OF HUMAN GENETICS 23:481-485(2015).
- Zhang, Y; Yao, J; et al. GNAI3 inhibits tumor cell migration and invasion and is post-transcriptionally regulated by miR-222 in hepatocellular carcinoma. CANCER LETTERS 356:978-984(2015).
