GMPS
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Official Full Name
guanine monphosphate synthetase -
Overview
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. -
Synonyms
GMPS;guanine monphosphate synthetase;GMP synthase [glutamine-hydrolyzing];GMP synthase;GMP synthetase;MLL/GMPS fusion protein;glutamine amidotransferase;guanosine 5-monophosphate synthase
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
GMPS involved in several pathways and played different roles in them. We selected most pathways GMPS participated on our site, such as Purine metabolism,Drug metabolism - other enzymes,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GMPS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | POLE3,NT5C3A,PDE4D,NME2A,IMPDH2,POLR1B,NT5C1A,ADSSL1,AK9,AK1 |
| Metabolic pathways | ADKA,NDUFS2,AOX3L1,ALDOCB,PANK4,NT5C2,INPP5K,PTGIS,AK7B,ALDOB |
| Drug metabolism - other enzymes | UGT2A1,NAT1,UGT1A4,UGT1AB,UPB1,UMPS,XDH,CYP2A6,UCKL1,Ces2e |
Protein Function
GMPS has several biochemical functions, for example, ATP binding,GMP synthase (glutamine-hydrolyzing) activity,GMP synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GMPS itself. We selected most functions GMPS had, and list some proteins which have the same functions with GMPS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PTK2B,ACSF3,NAIP1,ERBB4A,MAPK14,STYK1,UBA3,PAPSS2,ITK,STK3 |
| pyrophosphatase activity | CANT1A,ALPL,DOM3Z,PRUNE2,PHOSPHO1,CANT1B,NUDT19 |
Interacting Protein
GMPS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GMPS here. Most of them are supplied by our site. Hope this information will be useful for your research of GMPS.
USP7;VCAM1;HLA-B;HLA-C;IKBKE;TCEAL1;DDA1;BABAM1;PRKAG2;PRKAB1;AGPAT2;ZNF16;manX;15-deoxy-delta(12,14;FN1;PAX6
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References
- Venable, AS; Williams, RR; et al. An analysis of endothelial microparticles as a function of cell surface antibodies and centrifugation techniques. JOURNAL OF IMMUNOLOGICAL METHODS 406:117-123(2014).
- Zhan, WB; Wang, XL; et al. The VP37-binding protein F(1)ATP synthase beta subunit involved in WSSV infection in shrimp Litopenaeus vannamei. FISH & SHELLFISH IMMUNOLOGY 34:228-235(2013).
