GLYCTK

Official Full Name

glycerate kinase
Overview

This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described.
Synonyms

GLYCTK;glycerate kinase;HBEBP2;HBEBP4;CG9886 like;GLYCTK1;HBeAg binding protein 2;HBeAg binding protein 4;HBeAgBP4A;HBeAg-binding protein 2

Recombinant Proteins

Type:

Recombinant Proteins

Cell & Tissue Lysates

Protein Pre-coupled Magnetic Beads

Filters:

Species

Rat
Zebrafish
Mouse
Human

Source

Mammalian Cell
HEK293
HEK293T
Wheat Germ
In Vitro Cell Free System

Tag

His
Non
His&Fc&Avi
Myc&DDK
GST

Cat.#	Product name	Source (Host)	Species	Tag	Protein Length	Price
GLYCTK-2582R	Recombinant Rat GLYCTK Protein	Mammalian Cell	Rat	His		Inquiry
GLYCTK-4720Z	Recombinant Zebrafish GLYCTK	Mammalian Cell	Zebrafish	His		Inquiry
GLYCTK-6444M	Recombinant Mouse GLYCTK Protein	Mammalian Cell	Mouse	His		Inquiry
GLYCTK-5887HCL	Recombinant Human GLYCTK 293 Cell Lysate	HEK293	Human	Non		Inquiry
GLYCTK-2237R	Recombinant Rat GLYCTK Protein, His (Fc)-Avi-tagged	HEK293	Rat	His&Fc&Avi		Inquiry
GLYCTK-2237R-B	Recombinant Rat GLYCTK Protein Pre-coupled Magnetic Beads	HEK293	Rat			Inquiry
Glyctk-3235M	Recombinant Mouse Glyctk Protein, Myc/DDK-tagged	HEK293T	Mouse	Myc&DDK		Inquiry
GLYCTK-3619M	Recombinant Mouse GLYCTK Protein, His (Fc)-Avi-tagged	HEK293	Mouse	His&Fc&Avi		Inquiry
GLYCTK-3619M-B	Recombinant Mouse GLYCTK Protein Pre-coupled Magnetic Beads	HEK293	Mouse			Inquiry
GLYCTK-4999H	Recombinant Human GLYCTK Protein, GST-tagged	Wheat Germ	Human	GST		Inquiry
GLYCTK-5365HF	Recombinant Full Length Human GLYCTK Protein, GST-tagged	In Vitro Cell Free System	Human	GST	Full L. 523 amino acids	Inquiry

Background

What is GLYCTK Protein?

The GLYCTK protein, also known as glycerate kinase, is important because it helps make a key enzyme in the sugar protein family. This enzyme plays a vital role in adding phosphate to (R)-glycerate, which is needed for breaking down serine and processing fructose. If there's not enough GLYCTK activity, it can cause D-glyceric aciduria, a disorder where metabolism doesn’t work properly. This gene is active in places like the liver and duodenum and could be a target for drug treatments because of its various roles in biology. It’s a part of essential pathways, including those for protein phosphorylation and fructose breakdown, and it’s connected to conditions such as juvenile myoclonic epilepsy. The enzyme's structure includes two subunits with an alpha helix and a beta sheet. It interacts with cellular structures and membranes, influencing growth and death processes in cells. Additionally, GLYCTK acts as a biomarker in cancer research, helping scientists study tumor behavior and how tumors might resist drugs.

What is the Function of GLYCTK Protein?

The GLYCTK protein, or glycerate kinase, is part of the sugar protein family and is crucial for metabolism in our bodies. It mainly works on the phosphorylation of (R)-glycerate, a step needed to break down certain amino acids and sugars, like serine and fructose. This enzyme helps convert (R)-glycerate into a usable form for energy or other functions. If GLYCTK doesn't work right, it can cause metabolic issues such as D-glyceric aciduria, which involves excess glyceric acid accumulation. This protein is active in various tissues, especially the liver and small intestine, and is also involved in important processes like cell growth and death. Overall, GLYCTK is vital for processing certain sugars and amino acids, and troubles with its function can lead to major metabolic challenges.

GLYCTK Related Signaling Pathway

The GLYCTK protein is pretty active when it comes to several important signaling pathways. It interacts with proteins located on both the cell skeleton and membrane, which are critical for processes like cell growth and programmed cell death, known as apoptosis. This means it helps manage when and how cells should multiply or self-destruct, keeping things balanced. Besides its role in cell signaling, GLYCTK is also key in metabolic pathways, particularly those involving the breakdown of sugars like fructose. This activity is crucial for maintaining energy balance in the body. Moreover, GLYCTK's functions have been linked to certain neurological conditions, including epilepsy and juvenile myoclonic seizures, highlighting its relevance not just in metabolism but also in nerve cell activity and brain health.

GLYCTK Related Diseases

GLYCTK, also known as glycerate kinase, plays a big part in how our bodies handle metabolism, and it's linked to some health problems because of this. One of the key issues is D-glyceric aciduria, a rare disorder where glyceric acid builds up and causes metabolic troubles. Plus, GLYCTK might be involved in brain-related issues like epilepsy and juvenile myoclonic seizures, likely because it affects metabolic paths that influence how the brain works. Even though scientists are still exploring these connections, understanding what GLYCTK does is vital for figuring out and possibly addressing these health challenges.

Bioapplications of GLYCTK

GLYCTK (Glycerate Kinase) has several bioapplications. It is involved in fructose metabolism and glycosaminoglycan metabolism pathways. GLYCTK is also used as a drug target for treating various diseases, including breast cancer, lung cancer, prostate cancer, neurodegenerative diseases, and inflammation. Additionally, GLYCTK serves as a biomarker for studying tumor development, invasiveness, metastasis, metabolism, and drug resistance.

Quality Guarantee

High Purity

Fig1. SDS-PAGE (GLYCTK-4999H)

Involved Pathway

GLYCTK involved in several pathways and played different roles in them. We selected most pathways GLYCTK participated on our site, such as Biosynthesis of antibiotics,Glycerolipid metabolism,Glycine, serine and threonine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLYCTK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycerolipid metabolism	ALDH2,Cel,CELL,DGAT1,AKR1B10,MOGAT3,ALDH7A1,MGLL,GK,PPAP2C
Glyoxylate and dicarboxylate metabolism	MUT,CAT,ACAT2,GCSHB,SHMT2,GCSH,SHMT1,AGXTA,GCSHA,GRHPRB
Glycine, serine and threonine metabolism	AGXTA,SRR,GNMT,GAMT,CBSB,ALAS1,AOC2,GRHPR,ALAS2,PSPH
Metabolic pathways	HSD3B7,ACSL1B,ME3,STT3B,SC5D,SUCLG1,UGT8A,PTGES2,AMY2A,NMRK2
Biosynthesis of antibiotics	ACAA2,EHHADH,GALM,UAP1L1,AGXT,CMBL,DLD,ECHS1,NME6,AK7

Protein Function

GLYCTK has several biochemical functions, for example, ATP binding,glycerate kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLYCTK itself. We selected most functions GLYCTK had, and list some proteins which have the same functions with GLYCTK. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	LIG3,DGKB,DDX58,PCCA,IRAK4,MAPK12,GC3,PRKAA2,UBE2G2,ITK
protein binding	KIF4A,AP1G1,PLEKHF2,VARS2,CETN3,KPNA3,HILPDA,SOD1,TXNL4B,NPPA

Interacting Protein

GLYCTK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLYCTK here. Most of them are supplied by our site. Hope this information will be useful for your research of GLYCTK.

TRIP13;TRIM42;TRIM27;KRT15;REL;GOLGA2

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