GLS2
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Official Full Name
glutaminase 2 (liver, mitochondrial) -
Overview
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well. At least one transcribed pseudogene has been found for this gene. -
Synonyms
GLS2;glutaminase 2 (liver, mitochondrial);glutaminase liver isoform, mitochondrial;GA;GLS;hLGA;LGA;L-glutaminase;glutaminase I;glutaminase GA;breast cell glutaminase;L-glutamine amidohydrolase;phosphate-activated glutaminase;phosphate-depende
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&T7
- His&Fc&Avi
- His&SUMO
Involved Pathway
GLS2 involved in several pathways and played different roles in them. We selected most pathways GLS2 participated on our site, such as Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,D-Glutamine and D-glutamate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| D-Glutamine and D-glutamate metabolism | GLUD1B,ybaS,GLUD2,GLUD1A,GLSA,GLUD1,GLS |
| Arginine biosynthesis | GLUD2,CPS1,GOT2A,GLUD1B,GLSA,GLUD1A,GLULB,GLS,NOS2B,GLULA |
| GABAergic synapse | GABRP,GNGT1,GABRR3,GABBR2,GABARAP,SLC38A3,GNG11,GNB4,GABRA4,GNG2 |
| Proximal tubule bicarbonate reclamation | SLC4A4,ATP1B3,ATP1B2,CA2,ATP1A3,GLS,ATP1B1,GLUD1,PCK1,ATP1A2 |
| Central carbon metabolism in cancer | AKT2,FLT3,HRAS,SLC2A2,FGFR1,SLC7A5,GLS,AKT1,PIK3CB,PDK1 |
| Alanine, aspartate and glutamate metabolism | NAT8L,GPT2L,CAD,GLUL,GFPT2,RIMKLA,GPT,GLULA,ADSS,GPT2 |
| Glutamatergic synapse | GNG11,DLGAP1,GNAI1,GRIA3,SLC1A2,GRIA2,SHANK2,GNAO1,GRM2,SLC38A1 |
| Metabolic pathways | MTHFD1,MT-ND4,CHDH,ENO2,ATP6V0A1B,TYRP1B,MGAT5,ME3,AMY2A,NAT |
| MicroRNAs in cancer | ROCK1,TNXB,CDC25A,ERBB3,ST14,NOTCH4,GLS,RECK,SIRT1,NOTCH3 |
Protein Function
GLS2 has several biochemical functions, for example, glutaminase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLS2 itself. We selected most functions GLS2 had, and list some proteins which have the same functions with GLS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutaminase activity | GLS,GLSA,NADSYN1 |
| protein binding | ZMYM2,EIF2AK2,TLR2,MDFI,PBXIP1,CTAG1B,ETS1,PPFIA1,FANCB,EIF4ENIF1 |
Interacting Protein
GLS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLS2.
GRHPR
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References
- Cardona, C; Sanchez-Mejias, E; et al. Expression of Gls and Gls2 Glutaminase Isoforms in Astrocytes. GLIA 63:365-382(2015).
- Botman, D; Tigchelaar, W; et al. Determination of Phosphate-activated Glutaminase Activity and Its Kinetics in Mouse Tissues using Metabolic Mapping (Quantitative Enzyme Histochemistry). JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 62:813-826(2014).
