GLIS3
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Official Full Name
GLIS family zinc finger 3 -
Overview
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. -
Synonyms
GLIS3;GLIS family zinc finger 3;zinc finger protein 515 , ZNF515;zinc finger protein GLIS3;MGC33662;FLJ38999;FLJ90578;GLI similar 3;GLI SIMILAR PROTEIN 3;Zinc finger protein 515;ZNF515;OK/KNS-cl.4;GLI-similar 3
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GLIS3-5103Z | Recombinant Zebrafish GLIS3 | Mammalian Cell | Zebrafish | His |
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| GLIS3-4964H | Recombinant Human GLIS3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GLIS3-5334HF | Recombinant Full Length Human GLIS3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 774 amino acids |
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Involved Pathway
GLIS3 involved in several pathways and played different roles in them. We selected most pathways GLIS3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GLIS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
GLIS3 has several biochemical functions, for example, metal ion binding,nucleic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLIS3 itself. We selected most functions GLIS3 had, and list some proteins which have the same functions with GLIS3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | CHPF,OVOL2,GLIS1,TRIM109,ZNF354A,GTF3AA,NOX1,CRYAA,MAP3K3,MAT1A |
| nucleic acid binding | ZFP385C,SRSF7B,RAG1,RBM24A,ZFP260,ZFP932,CL2,EIF4BB,ZFP423,TREX2 |
Interacting Protein
GLIS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLIS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLIS3.
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References
- Xu, L; Hazard, FK; et al. Genomic analysis of fibrolamellar hepatocellular carcinoma. HUMAN MOLECULAR GENETICS 24:50-63(2015).
- Hong, KW; Chung, M; et al. Meta-analysis of genome-wide association study of homeostasis model assessment beta cell function and insulin resistance in an East Asian population and the European results. MOLECULAR GENETICS AND GENOMICS 289:1247-1255(2014).
