GLIS1
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Official Full Name
GLIS family zinc finger 1 -
Overview
GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of;transcription (Kim et al., 2002 (PubMed 12042312)). -
Synonyms
GLIS1;GLIS family zinc finger 1;zinc finger protein GLIS1;FLJ36155;GLI-similar 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GLIS1-115H | Recombinant Human GLIS1 protein, arginine-tagged | E.coli | Human |
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| GLIS1-5901HCL | Recombinant Human GLIS1 293 Cell Lysate | HEK293 | Human | Non |
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| GLIS1-4962H | Recombinant Human GLIS1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GLIS1-5332HF | Recombinant Full Length Human GLIS1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 620 amino acids |
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Involved Pathway
GLIS1 involved in several pathways and played different roles in them. We selected most pathways GLIS1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GLIS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
GLIS1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,metal ion binding,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLIS1 itself. We selected most functions GLIS1 had, and list some proteins which have the same functions with GLIS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | MMP14B,TRERF1,ESRRGB,NUFIP1,ZFP689,ZKSCAN6,GNE,PCXA,KDM6A,Adcy4 |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | AEBP1,MSX1,BCL6,MNT,ARHGAP35,HIST2H3A,KLF12,ZBTB12.2,ESX1,ARID5B |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | GATA2,RAD21,RXRB,BARHL2,PAX9,NKX2-5,PLAGL1,BARX2,GATA5,ALX1 |
| RNA polymerase II regulatory region sequence-specific DNA binding | SP3,ZIK1,BARX1,BCL6A,ZNF773,HMX1,SATB1,PKNOX2,ZGLP1,CREB3 |
Interacting Protein
GLIS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLIS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLIS1.
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References
- Vadnais, C; Shooshtarizadeh, P; et al. Autocrine Activation of the Wnt/beta-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers. BIOLOGY OPEN 3:937-946(2014).
- Khalesi, E; Nakamura, H; et al. The Kruppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 441:499-506(2013).
