GLIPR2
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Official Full Name
GLI pathogenesis-related 2 -
Overview
Glioma pathogenesis-related protein 1, also known as Protein RTVP-1, GLIPR1 and GLIPR, is a single-pass membrane protein which belongs to the CRISP family. GLIPR1 / RTVP-1 was expressed in high levels in glioblastomas, whereas its expression in low-grade astrocytomas and normal brains was very low. Transfection of glioma cells with small interfering RNAs targeting GLIPR1 / RTVP-1 decreased cell proliferation in all the cell lines examined and induced cell apoptosis in some of them. Overexpression of GLIPR1 / RTVP-1 increased astrocyte and glioma cell proliferation and the anchorage-independent growth of the cells. In addition, overexpression of GLIPR1 / RTVP-1 rendered glioma cells more resistant to the apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand and serum deprivation. GLIPR1 / RTVP-1 regulated the invasion of glioma cells was evident by their enhanced migration through Matrigel and by their increased invasion in a spheroid confrontation assay. The increased invasive potential of the GLIPR1 / RTVP-1 overexpressors was also shown by the increased activity of matrix metalloproteinase 2 in these cells. The expression of GLIPR1 / RTVP-1 is correlated with the degree of malignancy of astrocytic tumors and that GLIPR1 / RTVP-1 is involved in the regulation of the growth, survival, and invasion of glioma cells. GLIPR1 / RTVP-1 is a potential therapeutic target in gliomas. -
Synonyms
C77180;GAPR-1;5730414A08Rik
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
GLIPR2 involved in several pathways and played different roles in them. We selected most pathways GLIPR2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GLIPR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
GLIPR2 has several biochemical functions, for example, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GLIPR2 itself. We selected most functions GLIPR2 had, and list some proteins which have the same functions with GLIPR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | IMPA2,PON3,DMRTC1B,AOC3,TLR13,HLA-G,PVRL1B,FLT3LG,SQSTM1,SRR |
Interacting Protein
GLIPR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLIPR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLIPR2.
p27958-pro_0000037566
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