GLI3

  • Official Full Name

    GLI family zinc finger 3

  • Overview

    This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.

  • Synonyms

    GLI3;GLI family zinc finger 3;GCPS, GLI Kruppel family member GLI3 , glioma associated oncogene family zinc finger 3 , Greig cephalopolysyndactyly syndrome , PHS;transcriptional activator GLI3;ACLS;DNA binding protein;oncogene GLI3;PAP A;PAPA

Recombinant Proteins

  • Zebrafish
  • Chicken
  • Human
  • Mouse
  • Mammalian Cells
  • HEK293
  • E.coli
  • Wheat Germ
  • His
  • Non
  • T7
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
GLI3-11747Z Recombinant Zebrafish GLI3 Mammalian Cells Zebrafish His
GLI3-4675C Recombinant Chicken GLI3 Mammalian Cells Chicken His
GLI3-5904HCL Recombinant Human GLI3 293 Cell Lysate HEK293 Human Non
GLI3-1707H Recombinant Human GLI3 protein, His & T7-tagged E.coli Human His&T7 Met111~Ser343
Gli3-1708M Recombinant Mouse Gli3 protein, His & T7-tagged E.coli Mouse His&T7 Ser303~Glu561
GLI3-2338H Recombinant Human GLI3 Protein (Met111-Ser343), N-His tagged E.coli Human His Met111-Ser343
GLI3-4956H Recombinant Human GLI3 Protein, GST-tagged Wheat Germ Human GST

    Involved Pathway

    GLI3 involved in several pathways and played different roles in them. We selected most pathways GLI3 participated on our site, such as cAMP signaling pathway,Hedgehog signaling pathway,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLI3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cAMP signaling pathway PLCE1,TSHR,PPARA,VAV3,PPP1CB,GRIN3B,PRKACB,RAP1A,DRD1A,PDE3B
    Hedgehog signaling pathway IHHB,PTCH2,PRKACA,PRKACG,PRKACB,WNT2,SHHA,WNT3A,ZIC2A,GSK3AA
    Basal cell carcinoma WNT5A,WNT2,HHIP,PTCH1,GLI2,AXIN1,TCF7L2,Shh,WNT4,WNT3
    Pathways in cancer ARAF,RALBP1,WNT5A,GSK3B,TRAF2,PDGFRA,FGF13,FZD8,NRAS,BMP4

    Protein Function

    GLI3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,beta-catenin binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLI3 itself. We selected most functions GLI3 had, and list some proteins which have the same functions with GLI3. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PDCD1,ATP1A2,RAD51C,MXD4,TFCP2,IGFL1,RGP1,AP1G1,CTSC,UBE2E3
    chromatin binding HMGB3,URI1,NFATC3,PATZ1,CRTC2,REST,MLL1,TAF2,SVEP1,MCM5
    RNA polymerase II core promoter proximal region sequence-specific DNA binding JUN,EHF,FEZF1,ARNT2,SKIL,ALS2CR8,POU2F3,AKNA,KLF17,IRF4
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISL1,KLF5,NR6A1,CREB3,SRF,ELK1,ZIC3,ONECUT2,IRF1,NRL
    beta-catenin binding MED12L,NUMB,TRPC4,TAX1BP3,SHROOM2,HDAC6,TCF7L1A,SALL1,SLC9A3R2,PTBP3
    histone acetyltransferase binding ETS1,SP1,TRIP4,KAT2B,CITED2,CEBPB,CREB1,FOXP3,SIRT2,TAF7
    histone deacetylase binding NR2C1,NUDT21,KLF4,CBX5,NR2E1,RFXANK,KAT2A,MECP2,TFAP4,SFPQ
    metal ion binding RHOV,B4GALT2,TROVE2,GALNT14,MTMR4,ACACB,FOXP3,CAR3,ZFP410,RC3H1
    transcription factor activity, sequence-specific DNA binding ARID4A,FOXN4,ZNF35,ZNF41,NEUROD2,ELF2,CTNNB1,PRRX2,MYCB,STAT1A

    Interacting Protein

    GLI3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLI3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLI3.

    SUFU;STK36;Zic1;Zic2;SMAD1;Zic3;Pias1;q8cln9_yerpe;Sufu;YWHAE

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