GIF
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Official Full Name
gastric intrinsic factor (vitamin B synthesis) -
Overview
Intrinsic factor promotes absorption of the essential vitamin Cobalamin (Cbl) in the ileum by specific receptor mediated endocytosis. Defects in the gene GIF are the cause of hereditary intrinsic factor deficiency (IFD) also called congenital pernicious anemia. IFD is an autosomal recessive disorder characterized by megaloblastic anemia. -
Synonyms
Gastric Intrinsic Factor;Gastric intrinsic factor (vitamin B synthesis);GIF;IF;IFMH;INF;Intrinsic factor;TCM3;TCN3;Intrinsic Factor Ab
Recombinant Proteins
- Human
- Rat
- Mouse
- Arabidopsis thaliana
- Sf9 Insect Cell
- Mammalian Cell
- Insect Cell
- E.coli
- Human Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- Non
- His
- HIS
- His&T7
- His&Fc&Avi
- GST
Involved Pathway
GIF involved in several pathways and played different roles in them. We selected most pathways GIF participated on our site, such as Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with GIF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vitamin digestion and absorption | SLC52A3,APOA1,MMACHC,SCARB1,BTD,SLC19A3,SLC5A6,ABCC1,SLC46A1,SLC19A2 |
Protein Function
GIF has several biochemical functions, for example, cobalamin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GIF itself. We selected most functions GIF had, and list some proteins which have the same functions with GIF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cobalamin binding | MUT,TCNL,CUBN,LMBRD1,TCN1,MMACHC,CD320,TCN2 |
Interacting Protein
GIF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GIF here. Most of them are supplied by our site. Hope this information will be useful for your research of GIF.
CUBN
Resources
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References
- Gago, M; Cornell, LD; et al. Kidney Allograft Inflammation and Fibrosis, Causes and Consequences. AMERICAN JOURNAL OF TRANSPLANTATION 12:1199-1207(2012).
- Quadros, EV; et al. Advances in the understanding of cobalamin assimilation and metabolism. BRITISH JOURNAL OF HAEMATOLOGY 148:195-204(2010).
