GGT6
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Official Full Name
gamma-glutamyltransferase 6 -
Overview
GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular;enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl;moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione;synthesis (Heisterkamp et al., 2008 (PubMed 18357469)). -
Synonyms
GGT6;gamma-glutamyltransferase 6;gamma glutamyltransferase 6 homolog (rat);FLJ90165;Gamma glutamyltranspeptidase 6;GGT 6;gamma-glutamyltranspeptidase 6;gamma-glutamyltransferase 6 homolog
Recombinant Proteins
- Rat
- Mouse
- Human
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GGT6-2524R | Recombinant Rat GGT6 Protein | Mammalian Cell | Rat | His |
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| GGT6-6333M | Recombinant Mouse GGT6 Protein | Mammalian Cell | Mouse | His |
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| GGT6-701HCL | Recombinant Human GGT6 cell lysate | Human | Non |
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| GGT6-2180R | Recombinant Rat GGT6 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GGT6-2180R-B | Recombinant Rat GGT6 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GGT6-3545M | Recombinant Mouse GGT6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GGT6-3545M-B | Recombinant Mouse GGT6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GGT6-4878H | Recombinant Human GGT6 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GGT6-5242HF | Recombinant Full Length Human GGT6 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 493 amino acids |
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Involved Pathway
GGT6 involved in several pathways and played different roles in them. We selected most pathways GGT6 participated on our site, such as Aflatoxin activation and detoxification,Biological oxidations,Cyanoamino acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GGT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cyanoamino acid metabolism | SHMT2,GGT1A,GBA3,GGT1,GGT5,GGT7,GGT5A,SHMT1 |
| Metabolic pathways | NAMPT,CES1,FASN,MRI1,PLCZ1,ALDH5A1,SI,DGAT2,NME1-NME2,CERS5 |
| Glutathione conjugation | AKR1A1,GSTO2,GGTLC1,GSTK1 |
| Aflatoxin activation and detoxification | ACY3.2,CYP3C4,GGTLC1,CYP2A13,CYP2Y3,CYP3A5,CYP3A4,CYP3C1,DPEP2,ACY3.1 |
| Glutathione metabolism | GSTP1,GPX1,GSTM2,GSTM1,GSTP2,GSTM4,TXNDC12,GSTM6,G6PDX,ODC1 |
| Glutathione synthesis and recycling | GGTLC1 |
| Metabolism | PRKRA,LPA,ELA2,ACOT6,B3GNT3,MED26,GLIPR1,HELZ2,CPNE3,ADHFE1 |
| Biological oxidations | CYP46A1,BPNT1,CYP21A2,CYP2A6,CYP27B1,CYP11A1,ADH1A,CYP2C18,AS3MT,CYP8B2 |
Protein Function
GGT6 has several biochemical functions, for example, gamma-glutamyltransferase activity,glutathione hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GGT6 itself. We selected most functions GGT6 had, and list some proteins which have the same functions with GGT6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione hydrolase activity | GGT5,GGT1,GGT7 |
| gamma-glutamyltransferase activity | GGT5,GGT7,GGTLC1,GGT5A,GGT1A,GGT1 |
Interacting Protein
GGT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GGT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GGT6.
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