GFI1B
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Official Full Name
growth factor independent 1B transcription repressor -
Overview
GFI1b and its homolog GFI1 are transcriptional repressors and important regulators of erythroid and megakaryocytic development and differentiation (1,2). GFI1b negatively regulates transcription by recruiting chromatin regulatory proteins including CoREST -
Synonyms
GFI1B;growth factor independent 1B transcription repressor;growth factor independent 1B (potential regulator of CDKN1A, translocated in CML);zinc finger protein Gfi-1b;growth factor independent protein 1B;potential regulator of CDKN1A translocated in
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GFI1B-6648C | Recombinant Chicken GFI1B | Mammalian Cell | Chicken | His |
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| GFI1B-8277Z | Recombinant Zebrafish GFI1B | Mammalian Cell | Zebrafish | His |
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| GFI1B-695HCL | Recombinant Human GFI1B cell lysate | Human | Non |
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| GFI1B-4850H | Recombinant Human GFI1B Protein, GST-tagged | Wheat Germ | Human | GST |
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| GFI1B-5324HF | Recombinant Full Length Human GFI1B Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 330 amino acids |
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Involved Pathway
GFI1B involved in several pathways and played different roles in them. We selected most pathways GFI1B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GFI1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
GFI1B has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GFI1B itself. We selected most functions GFI1B had, and list some proteins which have the same functions with GFI1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF823,MCM3AP,SCML1,MSXA,ADAR,JUNB,EN2,PLSCR1,POLDIP2,RXRGA |
| RNA polymerase II transcription factor binding | WWP2,SPOP,MKX,HCLS1,MTDH,CHST13,GATA2,TBX3,SPI1,ZFPM2 |
| protein binding | TCEB1,PSMD11,RNF185,SPAG8,XAGE3,PPP2R2C,RPL23A,SSX1,RPS7,RNF7 |
| metal ion binding | DNLZ,NRXN1,KCND1,ZSCAN18,ZBTB37,RBM4.2,ZNF324,PTGS2,ERI3,ALPPL2 |
Interacting Protein
GFI1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFI1B here. Most of them are supplied by our site. Hope this information will be useful for your research of GFI1B.
NELL2;CENPJ;JAG2;BEGAIN;AGRN;HGS;KALRN;MEGF6;EFEMP2;CENPB;LAMB1;ACTN1;TRIM27;TAF1
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References
- Stevenson, WS; Morel-Kopp, MC; et al. Platelets are not all gray in GFI1B disease. CLINICAL GENETICS 87:299-299(2015).
- Lee, C; Northcott, PA; et al. REGULATION OF MEDULLOBLASTOMA FORMATION BY Gfi1 AND Gfi1B. NEURO-ONCOLOGY 16:-(2014).
