GEMIN4
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Official Full Name
gem (nuclear organelle) associated protein 4 -
Overview
The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] -
Synonyms
GEMIN4;gem (nuclear organelle) associated protein 4;p97;HC56;HCAP1;HHRF-1;gem-associated protein 4;gemin-4;component of gems 4;HCC-associated protein 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GEMIN4-13222H | Recombinant Human GEMIN4, His-tagged | E.coli | Human | His | C-term-356a.a. | |
| GEMIN4-2654Z | Recombinant Zebrafish GEMIN4 | Mammalian Cell | Zebrafish | His |
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| GEMIN4-5456C | Recombinant Chicken GEMIN4 | Mammalian Cell | Chicken | His |
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| GEMIN4-4840H | Recombinant Human GEMIN4 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
GEMIN4 involved in several pathways and played different roles in them. We selected most pathways GEMIN4 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with GEMIN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | SRRM1,EEF1A1B,THOC4,THOC5,NUP93,NUP98,RPP21,SEH1L,NUP210,RAN |
Protein Function
GEMIN4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GEMIN4 itself. We selected most functions GEMIN4 had, and list some proteins which have the same functions with GEMIN4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MEN1,PSMB5,PAFAH1B1,LSM2,FRS2,LCE1B,PLIN1,C4BP,ZFAND6,ARAF |
Interacting Protein
GEMIN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GEMIN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GEMIN4.
DDX20;SNRPB;SMN1;SNRPE;Snrpd1;Snrpd2;Snrpd3
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References
- Gedik, H; Erdal, ME; et al. Association of microRNA Biogenesis Pathway Gene Variants and Alcohol Dependence Risk. DNA AND CELL BIOLOGY 34:220-226(2015).
- Alazami, AM; Patel, N; et al. Accelerating Novel Candidate Gene Discovery in Neurogenetic Disorders via Whole-Exome Sequencing of Prescreened Multiplex Consanguineous Families. CELL REPORTS 10:148-161(2015).
