GEM
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Official Full Name
GTP binding protein overexpressed in skeletal muscle -
Overview
The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. -
Synonyms
GEM;GTP binding protein overexpressed in skeletal muscle;GTP-binding protein GEM;kinase inducible Ras like protein;KIR;GTP binding mitogen induced T cell protein;GTP binding protein expressed in mitogen stimulated T cells;GTP binding protein GEM;MGC26294;RAS like protein KIR;OTTHUMP00000226600;OTTHUMP00000226601;RAS-like protein KIR;kinase-inducible Ras-like protein;GTP-binding mitogen-induced T-cell protein;GTP-binding protein overexpressed in skeletal muscle
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GEM-13221H | Recombinant Human GEM, GST-tagged | E.coli | Human | GST | 1-296a.a. | |
| GEM-4427Z | Recombinant Zebrafish GEM | Mammalian Cells | Zebrafish | His |
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| GEM-628H | Recombinant Human GEM Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| GEM-6299M | Recombinant Mouse GEM Protein | Mammalian Cells | Mouse | His |
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| GEM-7132C | Recombinant Chicken GEM | Mammalian Cells | Chicken | His |
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| GEM-5961HCL | Recombinant Human GEM 293 Cell Lysate | HEK293 | Human | Non |
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| Gem-3187M | Recombinant Mouse Gem Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| GEM-3529M | Recombinant Mouse GEM Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GEM-3529M-B | Recombinant Mouse GEM Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GEM-6467H | Recombinant Human GEM Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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Involved Pathway
GEM involved in several pathways and played different roles in them. We selected most pathways GEM participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GEM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
GEM has several biochemical functions, for example, GDP binding,GTP binding,GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GEM itself. We selected most functions GEM had, and list some proteins which have the same functions with GEM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | HRASA,ACSM5,AGAP1,SEPT7,RAB7A,RAB7L1,FPGT,ERAL1,RASL11A,GNA11A |
| magnesium ion binding | RRAGC,NUDT7,Atp8a2,PCK1,TDP2B,ADPRH,NT5C1A,NUDT3,MAST4,FAN1 |
| calmodulin binding | KCNH5,MYO1G,ASPM,PLA2G6,KCNN1A,CAMKK1,MARCKSA,TRPV4,PATE4,MYH4 |
| GTPase activity | LRRK2,RAC2,GFM1,RAC3,GNAL,GNAI2A,RHOT1A,AGAP2,RHOJ,RAB3DA |
| GDP binding | RAB27A,RAB7A,RALB,RRAGC,RAB12,RAB7L1,RAP2B,RHOB,ARL8B,SRP54A |
| protein binding | CRX,SHMT1,SH2D3A,MAST2,ACYP2,ZNHIT6,ECHS1,GRB2,GSTZ1,UBL4B |
Interacting Protein
GEM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GEM here. Most of them are supplied by our site. Hope this information will be useful for your research of GEM.
TRIM23;CCDC102B;CCDC67;147700;AHCYL1
Resources
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References
- Hiroshima, Y; Maawy, AA; et al. Selective Efficacy of Zoledronic Acid on Metastasis in a Patient-Derived Orthotopic Xenograph (PDOX) Nude-Mouse Model of Human Pancreatic Cancer. JOURNAL OF SURGICAL ONCOLOGY 111:311-315(2015).
- Rowley, JS; Gray, SM; et al. Screening Potato Cultivars for new Sources of Resistance to Potato virus Y. AMERICAN JOURNAL OF POTATO RESEARCH 92:38-48(2015).
