GCNT1
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Official Full Name
glucosaminyl (N-acetyl) transferase 1, core 2 -
Overview
This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
GCNT1;glucosaminyl (N-acetyl) transferase 1, core 2;glucosaminyl (N acetyl) transferase 1, core 2 (beta 1,6 N acetylglucosaminyltransferase) , NACGT2;beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase;beta 1;3 galact
Recombinant Proteins
- Human
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GCNT1-13198H | Recombinant Human GCNT1, GST-tagged | E.coli | Human | GST | 41-428a.a. | |
| GCNT1-617H |
Active Recombinant Human Glucosaminyl (N-acetyl) Transferase 1, Core 2, His-tagged
|
Mammalian Cells | Human | His | 33-428 a.a. |
|
| GCNT1-714H |
Active Recombinant Human GCNT1, His-tagged
|
Mammalian Cells | Human | His | 33-428 a.a. |
|
| GCNT1-27452TH | Recombinant Human GCNT1 | Wheat Germ | Human | Non | 428 amino acids |
|
| GCNT1-5980HCL | Recombinant Human GCNT1 293 Cell Lysate | HEK293 | Human | Non |
|
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| GCNT1-195HF | Recombinant Full Length Human GCNT1 Protein | In Vitro Cell Free System | Human | Full L. 428 amino acids |
|
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| GCNT1-3025H | Recombinant Human GCNT1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
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| GCNT1-3025H-B | Recombinant Human GCNT1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| GCNT1-4804H | Recombinant Human GCNT1 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| GCNT1-5185HF | Recombinant Full Length Human GCNT1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 428 amino acids |
|
Involved Pathway
GCNT1 involved in several pathways and played different roles in them. We selected most pathways GCNT1 participated on our site, such as Mucin type O-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | AMPD3B,PYGL,CNDP2,GGPS1,HMBSB,CHKA,ME3,HSD3B5,GALNT3,HGD |
| Mucin type O-Glycan biosynthesis | GALNTL6,WBSCR17,GALNT2,GALNT9,GALNTL2,ST3GAL1,C1GALT1B,GALNT7,C1GALT1,ST6GALNAC1 |
Protein Function
GCNT1 has several biochemical functions, for example, beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCNT1 itself. We selected most functions GCNT1 had, and list some proteins which have the same functions with GCNT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity | GCNT4,GCNT3,GCNT4A |
| protein binding | EME1,PRNP,MAGEA8,SPINLW1,PIK3C2B,STK40,CFI,MLF1IP,SNAI1,ASB2 |
Interacting Protein
GCNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GCNT1.
GOLPH3;SEC24D;LAP3;CLTC;HSPA14;RSU1;CCDC80;VPS36;STMN2;CCT7;OSBPL1A;PARVA
Resources
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References
- Petrosyan, A; Holzapfel, MS; et al. Restoration of Compact Golgi Morphology in Advanced Prostate Cancer Enhances Susceptibility to Galectin-1-Induced Apoptosis by Modifying Mucin O-Glycan Synthesis. MOLECULAR CANCER RESEARCH 12:1704-1716(2014).
- Chen, ZX; Gulzar, ZG; et al. Increased Expression of GCNT1 is Associated With Altered O-glycosylation of PSA, PAP, and MUC1 in Human Prostate Cancers. PROSTATE 74:1059-1067(2014).
