GBA2
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Official Full Name
glucosidase, beta (bile acid) 2 -
Overview
This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism. -
Synonyms
GBA2;glucosidase, beta (bile acid) 2;non-lysosomal glucosylceramidase;AD035;bile acid beta glucosidase;DKFZp762K054;KIAA1605;non lysosomal glucosylceramidase;MGC16895;Beta glucocerebrosidase 2;Beta glucosidase 2;Glucosylceramidase 2;NLGase;beta-glucosidase 2;beta-glucocerebrosidase 2;bile acid beta-glucosidase
Recombinant Proteins
- Human
- Mouse
- Rat
- HEK293
- Mammalian Cell
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- Mammalian cells
- Myc&DDK
- His
- Non
- His&Fc&Avi
- GST
- Flag
Involved Pathway
GBA2 involved in several pathways and played different roles in them. We selected most pathways GBA2 participated on our site, such as Other glycan degradation,Sphingolipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GBA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Other glycan degradation | NEU3.1,NEU4,NEU2,ENGASE,NEU3.2,FUCA1,HEXB,FUCA1.2,NEU3.4,HEXA |
| Sphingolipid metabolism | GLTPD1,SPTLC1,PPAP2B,NEU2,SERINC1,SMPD2A,COL4A3BP,SGMS1,CERS2,SGPP2 |
| Metabolic pathways | B3GNT6,PLD3,PRPS1B,GCNT4,CERS1,OGDH,PYCRL,MTMR7B,PLCB3,ATP6V0D2 |
Protein Function
GBA2 has several biochemical functions, for example, beta-glucosidase activity,glucosylceramidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GBA2 itself. We selected most functions GBA2 had, and list some proteins which have the same functions with GBA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glucosylceramidase activity | GBA |
| beta-glucosidase activity | GBA3 |
Interacting Protein
GBA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GBA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GBA2.
mtlA;ILVBL;MRPS22;LAMTOR5;PPFIA1;MRPL44;SRP68;BAG5;AFG3L2
Resources
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References
- Burke, DG; Heales, SJ; et al. Lysosomal beta-glucosidase (GBA1) and non-lysosomal beta-glucosidase (GBA2): Potential involvement in the pathogenesis of Gaucher disease/Parkinson disease. MOLECULAR GENETICS AND METABOLISM 114:S26-S26(2015).
- Sansenya, S; Mutoh, R; et al. Expression and crystallization of a bacterial glycoside hydrolase family 116 beta-glucosidase from Thermoanaerobacterium xylanolyticum. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 71:41-44(2015).
