GATA5

  • Official Full Name

    GATA binding protein 5

  • Overview

    The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.

  • Synonyms

    GATA5;GATA binding protein 5;transcription factor GATA-5;bB379O24.1;GATA-binding factor 5;GATA5_HUMAN;GATA binding factor-5;GATA-binding protein 5

Recombinant Proteins

  • Mouse
  • Chicken
  • Zebrafish
  • Rat
  • Human
  • Mammalian Cells
  • E.coli
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • Avi
  • Fc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
GATA5-6226M Recombinant Mouse GATA5 Protein Mammalian Cells Mouse His
GATA5-6972C Recombinant Chicken GATA5 Mammalian Cells Chicken His
GATA5-8834Z Recombinant Zebrafish GATA5 Mammalian Cells Zebrafish His
Gata5-1567M Recombinant Mouse Gata5 Protein, His-tagged E.coli Mouse His Met1-Leu401
Gata5-1568R Recombinant Rat Gata5 Protein, His-tagged E.coli Rat His Met1-Ala397
GATA5-3484M Recombinant Mouse GATA5 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
GATA5-3484M-B Recombinant Mouse GATA5 Protein Pre-coupled Magnetic Beads HEK293 Mouse
GATA5-4751H Recombinant Human GATA5 Protein, GST-tagged Wheat Germ Human GST
GATA5-5470HF Recombinant Full Length Human GATA5 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 397 amino acids

    Involved Pathway

    GATA5 involved in several pathways and played different roles in them. We selected most pathways GATA5 participated on our site, such as Factors involved in megakaryocyte development and platelet production,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hemostasis BRPF3,DOCK2,MFN1,DGKQ,GRB7,DOCK10,CFHL2,KCNMB2,PDE10A,TRPC7
    Factors involved in megakaryocyte development and platelet production HBG1,VPS45,CENPE,NFE2,HBG2,DOCK11,IRF2,MAFG,IRF1B,GATA2A

    Protein Function

    GATA5 has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA5 itself. We selected most functions GATA5 had, and list some proteins which have the same functions with GATA5. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription factor binding GATA1,TP53,SFPI1,SPI1,NFATC1,TRP53,CREBBP,GATA2B,MKX,KDM1A
    enhancer sequence-specific DNA binding SOX11,MYT1,TFAP2B,LMO4,TWIST1B,GATA2,HMGB2,FOXN4,ISL1,XBP1
    zinc ion binding ATRX,LONRF2,MEX3C,OAS1A,MARCH5L,ZNF34,BAZ2A,PEG10,ZFP330,SLC11A2
    RNA polymerase II regulatory region sequence-specific DNA binding GATA4,ARID3A,KAT2B,NHLH1,PKNOX2,ZNF691,SKINT8,GLIS1,SP5,ZNF549
    transcription regulatory region DNA binding MEF2C,MEN1,NCOR1,KLF4,CARM1,NR1D1,NFE2L2,FOXA1,YY1,REST
    transcription factor activity, sequence-specific DNA binding RXRAB,RELB,REL,TEAD2,NPAS2,PURBA,ZHX3,HMG20A,POU4F1,ZSCAN4C
    sequence-specific DNA binding MSXC,ARNTL,NR5A5,TFAP4,HOXC12A,SOX21A,DLX3B,HOXC8,DHARMA,ESR2A
    DNA binding Alb,ESR2B,ZFP654,ZFP768,ZNF524,RARAB,ZNF223,TAF6L,NUFIP1,INO80
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding RELA,SRF,SNAI2,PURA,GATA6,IRF8,FOXP3,SFPI1,CIR1,SOX10

    Interacting Protein

    GATA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA5.

    Resources

    References

    • Zhang, XL; Dai, N; et al. GATA5 loss-of-function mutation in familial dilated cardiomyopathy. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 35:763-770(2015).
    • Wang, J; Mao, JH; et al. A Novel NKX2.6 Mutation Associated with Congenital Ventricular Septal Defect. PEDIATRIC CARDIOLOGY 36:646-656(2015).

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