GATA4

  • Official Full Name

    GATA binding protein 4
  • Overview

    This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq, Jul 2008]
  • Synonyms

    GATA4;GATA binding protein 4;ASD2;VSD1;TACHD;transcription factor GATA-4;GATA-binding factor 4

Recombinant Proteins

  • Rat
  • Human
  • Chicken
  • Zebrafish
  • Mouse
  • Mammalian Cells
  • Wheat Germ
  • E.coli
  • HEK293
  • His
  • Non
  • Avi
  • Fc
  • Myc
  • DDK
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
GATA4-2482R Recombinant Rat GATA4 Protein Mammalian Cells Rat His
GATA4-28985TH Recombinant Human GATA4 Wheat Germ Human Non 100 amino acids
GATA4-535H Recombinant Human GATA4 Protein, His-tagged E.coli Human His Arg201~Ala442
Gata4-536R Recombinant Rat Gata4 Protein, His-tagged E.coli Rat His Arg228~Ala440
GATA4-5529C Recombinant Chicken GATA4 Mammalian Cells Chicken His
GATA4-8835Z Recombinant Zebrafish GATA4 Mammalian Cells Zebrafish His
GATA4-6010HCL Recombinant Human GATA4 293 Cell Lysate HEK293 Human Non
GATA4-2138R Recombinant Rat GATA4 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
GATA4-2138R-B Recombinant Rat GATA4 Protein Pre-coupled Magnetic Beads HEK293 Rat
GATA4-2441M Recombinant Mouse GATA4 Protein (1-441 aa), His-Myc-tagged E.coli Mouse His&Myc 1-441 aa
GATA4-3194H Recombinant Human GATA4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
GATA4-501HFL Active Recombinant Full Length Human GATA4 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
GATA4-580H Active Recombinant Human GATA4 Protein, Myc/DDK-tagged HEK293 Human DDK&Myc
GATA4-964H Recombinant Human GATA4 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
GATA4-964H-B Recombinant Human GATA4 Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    GATA4 involved in several pathways and played different roles in them. We selected most pathways GATA4 participated on our site, such as cGMP-PKG signaling pathway,Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone signaling pathway PIK3CG,ESR1,WNT4,CASP9,MDM2,PLCD1,MED27,SLC9A1,PLCB1,PLCE1
    cGMP-PKG signaling pathway PPP3CC,PLCB4,VDAC1,PLCB3,PRKCE,NPR2,CALM4,MEF2D,RHOA,PPP3CA

    Protein Function

    GATA4 has several biochemical functions, for example, DNA binding,NFAT protein binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA4 itself. We selected most functions GATA4 had, and list some proteins which have the same functions with GATA4. You can find most of the proteins on our site.

    Function Related Protein
    chromatin binding NFATC2,JUN,CDK9,SP140,TLE1,HOXC13,TFAM,HMGXB4A,MEF2C,SUPT5H
    enhancer sequence-specific DNA binding TWIST1B,TBX19,GATA2,YY1,GATA3,TFAP2B,HMGB2,KLF6A,SOX11,KLF7B
    DNA binding MYPOP,DNMT1,POLR1D,VDRA,PALB2,ZFP35,TAF13,SCML4,RPS3,HMGB1B
    RNA polymerase II regulatory region sequence-specific DNA binding ZMYND11,NHLH2,PRDM12B,ZNF583,ZFP39,AEBP1,AIRE,ETV3,GATA5,TBX5
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding TBX5,ZGLP1,CREBBP,SRF,MAFGB,GATA5,MAFBB,MSGN1,GATA2A,HSF2
    activating transcription factor binding PRDM16,MEF2D,MEF2A,PPARG,RELA,HDAC4,SMAD2,EP300,HDAC7A,HDAC7
    transcription coactivator activity VGLL1,STIL,PRPF6,PCBD1,BRD7,ARL2BP,TRIP4,JUP,BCL10,SP4
    transcription regulatory region DNA binding ERBB4,MLL1,HNRNPL,HMGB2,TFEB,KLF17,HHEX,TCF7L1B,LEF1,CCNT1
    RNA polymerase II transcription factor binding ZFPM2A,NFATC1,GATA6,GATA2B,GSK3B,TBX3,TEAD3,DHX9,XBP1,MEF2A

    Interacting Protein

    GATA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA4.

    KLF13

    Resources

    References

    • Yamak, A; Georges, RO; et al. Novel Exons in the Tbx5 Gene Locus Generate Protein Isoforms with Distinct Expression Domains and Function. JOURNAL OF BIOLOGICAL CHEMISTRY 290:6844-6856(2015).
    • Zheng, Y; Thomas, A; et al. Quantitative detection of human spermatogonia for optimization of spermatogonial stem cell culture. HUMAN REPRODUCTION 29:2497-2511(2014).

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