GALR1
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Official Full Name
galanin receptor 1 -
Overview
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors.Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways.GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family.GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. -
Synonyms
GALR1;galanin receptor 1;GALNR, GALNR1;galanin receptor type 1;GAL1-R;GALR-1;OTTHUMP00000163778;GALNR;GALNR1
Recombinant Proteins
- Rat
- Chicken
- Mouse
- Human
- Mus musculus
- Mammalian Cells
- HEK293
- E.coli
- His
- Flag
- His&Fc&Avi
Involved Pathway
GALR1 involved in several pathways and played different roles in them. We selected most pathways GALR1 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | GABRQ,GNRHR1,P2RX3,P2RY2,GRIN2BB,LEPA,TAAR8A,CHRNA2A,HTR5AL,GCGR |
Protein Function
GALR1 has several biochemical functions, for example, galanin receptor activity,neuropeptide binding,peptide hormone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GALR1 itself. We selected most functions GALR1 had, and list some proteins which have the same functions with GALR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| galanin receptor activity | GAL,GALR3,GALR2 |
| peptide hormone binding | GCGR,GHR,HCRTR1,NPR1,PTH1R,INHBA,AGTR1B,EDNRB,ANXA5,RXFP2 |
| neuropeptide binding | MRGPRB1,SSTR5,ADCYAP1R1,OPRD1,SSTR2,MC4R,OPRD1A,GPR1,MC3R,OPRM1 |
| protein binding | GCA,CNOT10,TNNI3,DUT,INS,BEND7,KCNH7,TCEB1,PMP2,RAB22A |
Interacting Protein
GALR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GALR1.
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References
- Guo, SC; Yan, FY; et al. Identification and validation of the methylation biomarkers of non-small cell lung cancer (NSCLC). Clinical Epigenetics 7:-(2015).
- Metcalf, CS; Klein, BD; et al. Analgesic Properties of a Peripherally Acting and GalR2 Receptor-Preferring Galanin Analog in Inflammatory, Neuropathic, and Acute Pain Models. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 352:185-193(2015).
