GALNT14
-
Official Full Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) -
Overview
GALNT14 (EC 2.4.1.41) belongs to a large subfamily of glycosyltransferases residing in the Golgi apparatus. GALNT enzymes catalyze the first step in the O-glycosylation of mammalian proteins by transferring N-acetyl-D-galactosamine (GalNAc) to peptide substrates. -
Synonyms
GALNT14;UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14);polypeptide N-acetylgalactosaminyltransferase 14;FLJ12691;GalNac T10;GalNac T14;GalNAc-T14;GLT14_HUMAN;Polypeptide GalNAc transferase 14;Polypeptide N acetylgalactosaminyltransferase 14;pp GaNTase 14;pp-GaNTase 14;Protein UDP acetylgalactosaminyltransferase 14;Protein-UDP acetylgalactosaminyltransferase 14;UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 14;UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14;polypeptide N-acetylgalactosaminyltransferase 15;UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T10;UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T14;GALNT15;GalNac-T10
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GALNT14-233H | Recombinant Human GALNT14 Protein, GST-His-tagged | E.coli | Human | His&GST |
|
|
| GALNT14-4075Z | Recombinant Zebrafish GALNT14 | Mammalian Cells | Zebrafish | His |
|
|
| GALNT14-6037HCL | Recombinant Human GALNT14 293 Cell Lysate | HEK293 | Human | Non |
|
|
| GALNT14-4659H | Recombinant Human GALNT14 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 1-552aa |
|
| GALNT14-4695H | Recombinant Human GALNT14 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| GALNT14-5198HF | Recombinant Full Length Human GALNT14 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 552 amino acids |
|
Involved Pathway
GALNT14 involved in several pathways and played different roles in them. We selected most pathways GALNT14 participated on our site, such as Mucin type O-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALNT14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PCK1,ASMT,ACSBG2,SPTLC1,GCNT2,ITPKB,ACAA2,ACADL,KCNG4,NADK2 |
| Mucin type O-Glycan biosynthesis | GCNT4,POC1BL,GALNT1,GALNTL6,ST6GALNAC1,WBSCR17,GALNT10,GCNT3,GALNT5,C1GALT1B |
Protein Function
GALNT14 has several biochemical functions, for example, carbohydrate binding,metal ion binding,polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GALNT14 itself. We selected most functions GALNT14 had, and list some proteins which have the same functions with GALNT14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| polypeptide N-acetylgalactosaminyltransferase activity | GALNTL1,GALNT9,GALNT13,GALNT10,GALNT3,GALNT4,GALNT11,GALNT5,GALNT1,GALNT2 |
| metal ion binding | ZFP541,ZNF701,ZFP292,Fcer2a,BMP1B,SMAD4,ZBTB2A,ZNF202,UQCRC2B,ZSCAN5A |
| carbohydrate binding | LGALS9C,REG3A,LGALS2B,LGALS2,FBXO2,EVA1C,PKD1L3,FCN1,Mgl2,CD34 |
Interacting Protein
GALNT14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALNT14 here. Most of them are supplied by our site. Hope this information will be useful for your research of GALNT14.
Resources
Related Services
Related Products
References
- Liang, KH; Yang, PC; et al. Genotyping the GALNT14 gene by joint analysis of two linked single nucleotide polymorphisms using liver tissues for clinical and geographical comparisons. ONCOLOGY LETTERS 8:2215-2220(2014).
- Yeh, CT; Liang, KH; et al. A single nucleotide polymorphism on the GALNT14 gene as an effective predictor of response to chemotherapy in advanced hepatocellular carcinoma. INTERNATIONAL JOURNAL OF CANCER 134:1214-1224(2014).
