GALE
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Official Full Name
UDP-galactose-4-epimerase -
Overview
This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild (peripheral form) to severe (generalized form). Multiple alternatively spliced transcripts encoding the same protein have been identified. -
Synonyms
GALE;UDP-galactose-4-epimerase;galactose 4 epimerase, UDP;UDP-glucose 4-epimerase;SDR1E1;short chain dehydrogenase/reductase family 1E;member 1;UDP glucose 4 epimerase;FLJ95174;FLJ97302;Galactose 4 epimerase UDP;Galactowaldenase;GALE_HUMAN;OTTHUMP00000002991;OTTHUMP00000002994;OTTHUMP00000037931;OTTHUMP00000044857;short chain dehydrogenase/reductase family 1E member 1;UDP galactose 4 epimerase;UDP-galactose 4-epimerase;UDP galactose-4-epimerase;galactose-4-epimerase, UDP-;short chain dehydrogenase/reductase family 1E, member 1
Recombinant Proteins
- Bacillus subtilis
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- E.Coli/Yeast
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- His&SUMO
- GST
Involved Pathway
GALE involved in several pathways and played different roles in them. We selected most pathways GALE participated on our site, such as Galactose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amino sugar and nucleotide sugar metabolism | RENBP,NANSA,PGM2,CYB5R1,CYB5R2,GPR19,TSTA3,CHIT1,GMPPAB,UXS1 |
| Galactose metabolism | aLA,GAA,SI,B4GALT2,AKR1B8,PFKM,GANC,PFKP,AKR1B10,UGP2B |
| Metabolic pathways | RDH12,ACO1,ACSBG1,B3GNT2,AGK,ST3GAL3B,HEXB,OGDH,TALDO1,CYP4F14 |
Protein Function
GALE has several biochemical functions, for example, UDP-N-acetylglucosamine 4-epimerase activity,UDP-glucose 4-epimerase activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GALE itself. We selected most functions GALE had, and list some proteins which have the same functions with GALE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | ATPIF1,PML,HNF1B,NAGA,ATP2A1,ODC1,ERP29,FBXO4,DEM1,TBX18 |
Interacting Protein
GALE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALE here. Most of them are supplied by our site. Hope this information will be useful for your research of GALE.
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References
- Hong, X; Lejeune, MA; et al. Stochastic network design for disaster preparedness. IIE TRANSACTIONS 47:329-357(2015).
- Goudge, TA; Mustard, JF; et al. Integrating CRISM and TES hyperspectral data to characterize a halloysite-bearing deposit in Kashira crater, Mars. ICARUS 250:165-187(2015).
