GAK

  • Official Full Name

    cyclin G associated kinase

  • Overview

    In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the cyclin box. In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5.

  • Synonyms

    GAK;cyclin G associated kinase;cyclin-G-associated kinase;auxilin 2;DNAJC26;auxilin-2;DNAJ26;FLJ16629;FLJ40395;MGC99654

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • Insect Cells
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • GST
  • His
  • Non
  • DDK&Myc
  • Flag
  • Avi&Fc&His

    Involved Pathway

    GAK involved in several pathways and played different roles in them. We selected most pathways GAK participated on our site, such as Clathrin derived vesicle budding,Golgi Associated Vesicle Biogenesis,Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Clathrin derived vesicle budding AP1G1,PICALM,TCEAL4,CLTA,BLOC1S1,PUM1,TPD52L1,CLINT1,SNX9,PLDN
    trans-Golgi Network Vesicle Budding HIP1R,FTH1B,PICALMB,CNO,TGOLN2,SH3D19,TPD52L1,FTH1A,SNAPIN,DTNBP1B
    Golgi Associated Vesicle Biogenesis PICALM,AP1M2,AP1B1,BLOC1S4,PLDN,BLOC1S3,TPD52L1,HIP1RB,SNX9B,DTNBP1B
    Vesicle-mediated transport HIP1RB,LOC479668,SEC22A,TFR1B,NECAP1,TPD52,RALAB,TCEAL4,HIP1R,SH3D19
    Membrane Trafficking PPP6R3,CLVS1,AP1S3A,CLVS2,BLOC1S1,RALAA,ARCN1B,CTSZ,PLDN,EXOC5

    Protein Function

    GAK has several biochemical functions, for example, ATP binding,protein binding,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GAK itself. We selected most functions GAK had, and list some proteins which have the same functions with GAK. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding BCS1L,VRK3,NSFB,DDX58,HIPK2,ATP9A,MYO6,TESK1,SLK,BTK
    protein binding DUSP1,GNG4,MRPL53,TMEM139,PHAX,DCTN1,ETS2,KLHL12,IGF2BP2,SEMA6A
    protein serine/threonine kinase activity NEK10,ICK,CAMK2G1,RAF1,TNNI3K,SGK2,MOK,CSNK1A1L,AURKA,CDK1

    Interacting Protein

    GAK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAK here. Most of them are supplied by our site. Hope this information will be useful for your research of GAK.

    LRRK2;ATP13A2;bosutinib;dasatinib;HSPA8

    Resources

    References

    • Chaikuad, A; Keates, T; et al. Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies. BIOCHEMICAL JOURNAL 459:59-69(2014).
    • Naito, Y; Shimizu, H; et al. Cyclin G-associated kinase regulates protein phosphatase 2A by phosphorylation of its B 'gamma subunit. CELL CYCLE 11:604-616(2012).

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