GADD45G
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Official Full Name
growth arrest and DNA-damage-inducible, gamma -
Overview
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. -
Synonyms
GADD45G;growth arrest and DNA-damage-inducible, gamma;growth arrest and DNA damage-inducible protein GADD45 gamma;CR6;DDIT2;gadd related protein;17 kD;GADD45gamma;growth arrest and DNA damage inducible gamma;GRP17;DDIT-2;GADD45-gamma;gadd-rela
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Human
- Rat
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- His&T7
- His&SUMO
- Myc&DDK
- GST
Involved Pathway
GADD45G involved in several pathways and played different roles in them. We selected most pathways GADD45G participated on our site, such as Cell cycle,DNA damage response,FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GADD45G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA damage response | GADD45A,TLK2,RAD9A,CDK5,HUS1B,RAD17,RAD1,CHEK2,DDB2 |
| MAPK signaling pathway | GNG12,HSPB1,TGFBR1,FLNB,RAP1B,Pdgfa&Pdgfb,RPS6KA5,MOS,CACNB3A,MAPK10 |
| p38 MAPK signaling pathway | MAP3K10,MAP3K9 |
| Cell cycle | KIF2A,CENPK,HUS1,CDK4,CDC16,SKA1,CENPQ,CNEP1R1,NCAPG,TFDP1 |
| IL12-mediated signaling events | EOMES,HLX |
| p53 signaling pathway | CD82,SESN3 |
| FoxO signaling pathway | FBXO32,SOD2,SGK3,PIK3CA,PLK2B,S1PR4,EP300,MAPK1,TGFBR1,SKP2 |
Protein Function
GADD45G has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GADD45G itself. We selected most functions GADD45G had, and list some proteins which have the same functions with GADD45G. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SEC22C,GSS,FZD10,RBL2,DOCK2,DCUN1D1,FCNA,CDC23,SOX7,MCRS1 |
Interacting Protein
GADD45G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GADD45G here. Most of them are supplied by our site. Hope this information will be useful for your research of GADD45G.
RWDD2B;UTP14A;GADD45GIP1;REL;CEP57L1;AFAP1L1
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